Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 7/20 | 0.65 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.65 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.65 |
| ▸ | MAOA | P21397 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.35 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.35 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1606201 | 1.00 | CYP11B2 (0.65) | CYP11B2CYP11B1CYP19A1MAOAKCNH2 | |
| SCHEMBL1605853 | 0.87 | CYP11B2 (0.62) | CYP11B2CYP11B1CYP19A1MAOA | |
| SCHEMBL1605732 | 0.87 | CYP11B2 (0.62) | CYP11B2CYP11B1CYP19A1MAOA | |
| SCHEMBL1605728 | 0.87 | CYP11B2 (0.62) | CYP11B2CYP11B1CYP19A1MAOA | |
| SCHEMBL28451312 | 0.85 | CYP11B2 (0.67) | CYP11B2CYP11B1CYP19A1MAOA | |
| SCHEMBL27935221 | 0.85 | CYP11B2 (0.61) | CYP11B2CYP11B1CYP19A1MAOAOPRL1 | |
| SCHEMBL19417479 | 0.83 | CYP11B2 (0.59) | CYP11B2CYP11B1CYP19A1MAOAKCNH2 | |
| SCHEMBL1606436 | 0.83 | CYP11B2 (0.56) | CYP11B2CYP11B1CYP19A1MAOAKCNH2 | |
| SCHEMBL1605733 | 0.83 | CYP11B2 (0.56) | CYP11B2CYP11B1CYP19A1MAOAKCNH2 | |
| SCHEMBL1605729 | 0.83 | CYP11B2 (0.56) | CYP11B2CYP11B1CYP19A1MAOAKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113166204-B | Cyclic peptides as inhibitors of proprotein convertase subtilisin/kexin type 9 (PCSK 9) for the treatment of metabolic disorders | 诺华股份有限公司 | 2025-01-28 | — | — | CN | disclosed |
| CN-113166114-B | Cyclic tetramer compounds as inhibitors of proprotein convertase subtilisin/KEXIN type 9 (PCSK 9) for the treatment of metabolic disorders | 诺华股份有限公司 | 2025-01-03 | — | — | CN | disclosed |
| WO-2023084449-A1 | DIAMINOCYCLOPENTYLPYRIDINE DERIVATIVES FOR THE TREATMENT OF A DISEASE OR DISORDER | NOVARTIS AG (CH) | 2023-05-19 | — | — | WO | disclosed |