Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 5/20 | 1.00 |
| ▸ | GUSB | P08236 | 7/20 | 0.58 |
| ▸ | EGFR | P00533 | 3/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.47 |
| ▸ | RELA | Q04206 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SNCA | P37840 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1252088 | 1.00 | DGAT1 (1.00) | DGAT1GUSBEGFRERBB2KDM4E | |
| SCHEMBL13881979 | 0.93 | DGAT1 (0.86) | DGAT1GUSB | |
| SCHEMBL1251902 | 0.91 | DGAT1 (0.83) | DGAT1GUSBEGFRKDM4ETP53 | |
| SCHEMBL1251954 | 0.91 | DGAT1 (0.83) | DGAT1GUSBALDH1A1NPC1RAB9A | |
| SCHEMBL1251973 | 0.91 | DGAT1 (0.83) | DGAT1GUSBKDM4EALDH1A1HSD17B10 | |
| SCHEMBL30385827 | 0.89 | DGAT1 (0.80) | DGAT1GUSBEGFRERBB2KDM4E | |
| SCHEMBL1252711 | 0.89 | DGAT1 (0.80) | DGAT1GUSBEGFRERBB2KDM4E | |
| SCHEMBL1252695 | 0.89 | DGAT1 (0.79) | DGAT1GUSB | |
| SCHEMBL1252721 | 0.88 | DGAT1 (0.79) | DGAT1GUSBEGFRERBB2KDM4E | |
| SCHEMBL1250498 | 0.88 | DGAT1 (1.00) | DGAT1GUSBEGFRERBB2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113166204-B | Cyclic peptides as inhibitors of proprotein convertase subtilisin/kexin type 9 (PCSK 9) for the treatment of metabolic disorders | 诺华股份有限公司 | 2025-01-28 | — | — | CN | disclosed |
| CN-113166114-B | Cyclic tetramer compounds as inhibitors of proprotein convertase subtilisin/KEXIN type 9 (PCSK 9) for the treatment of metabolic disorders | 诺华股份有限公司 | 2025-01-03 | — | — | CN | disclosed |
| WO-2023084449-A1 | DIAMINOCYCLOPENTYLPYRIDINE DERIVATIVES FOR THE TREATMENT OF A DISEASE OR DISORDER | NOVARTIS AG (CH) | 2023-05-19 | — | — | WO | disclosed |