Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 3/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 2/20 | 0.32 |
| ▸ | TTK | P33981 | 3/20 | 0.32 |
| ▸ | QPCT | Q16769 | 1/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.31 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22124796 | 1.00 | CDK2 (0.35) | CDK2CCNT1CCNA2CDK9CDK1 | |
| SCHEMBL22123589 | 0.93 | TTK (0.35) | TTKZAP70KARS1 | |
| SCHEMBL22124722 | 0.92 | PDE10A (0.35) | PTK2TTKZAP70KARS1 | |
| SCHEMBL24112394 | 0.92 | TTK (0.34) | PTK2TTKZAP70KARS1 | |
| SCHEMBL22124854 | 0.92 | PDE10A (0.35) | PTK2TTKZAP70KARS1 | |
| SCHEMBL25450808 | 0.91 | TTK (0.32) | PTK2TTKZAP70KARS1 | |
| SCHEMBL22124716 | 0.90 | TTK (0.31) | EGFRIGF1RTTK | |
| Formic Acid SCHEMBL22123789 | 0.90 | PDE10A (0.34) | PTK2TTKZAP70KARS1 | |
| SCHEMBL30171536 | 0.89 | BRD4 (0.39) | CCNT1CDK9EGFRTTKAXL | |
| SCHEMBL22123380 | 0.89 | ZAP70 (0.39) | PTK2TTKZAP70KARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4161931-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2023-04-12 | — | — | EP | disclosed |