Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1B | P47901 | 2/20 | 0.33 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.33 |
| ▸ | OXTR | P30559 | 1/20 | 0.33 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.33 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | CNR1 | P21554 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PTPN22 | Q9Y2R2 | 3/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.32 |
| ▸ | CNR2 | P34972 | 2/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3376447 | 0.93 | AVPR2 (0.37) | AVPR1BAVPR2OXTRAVPR1ALMNA | |
| SCHEMBL2188175 | 0.91 | NPC1 (0.38) | PTGER1NPC1LMNACNR1MAPT | |
| SCHEMBL2214141 | 0.87 | SLC6A9 (0.36) | AVPR1BAVPR2OXTRAVPR1ANPC1 | |
| SCHEMBL312209 | 0.85 | AVPR2 (0.41) | AVPR1BAVPR2OXTRAVPR1ALMNA | |
| SCHEMBL303235 | 0.84 | MAPT (0.41) | LMNAMAPTNAMPTMEN1KMT2A | |
| SCHEMBL2214352 | 0.79 | KDM4E (0.42) | AVPR1BAVPR2OXTRAVPR1ALMNA | |
| SCHEMBL303136 | 0.78 | HTT (0.38) | NPC1LMNACNR1MAPTKDM4E | |
| SCHEMBL303174 | 0.78 | HTT (0.41) | NPC1CNR1MAPTHTTSMN1; SMN2 | |
| SCHEMBL2188016 | 0.77 | KDM4E (0.43) | AVPR1APTGER1NPC1LMNAMAPT | |
| SCHEMBL3381042 | 0.73 | MEN1 (0.48) | OXTRLMNAMAPTNAMPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2012500836-A | — | — | 2012-01-12 | — | — | JP | claimed |
| EP-2342177-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | Xention Limited (GB) | 2011-07-13 | — | — | EP | claimed |
| WO-2010023448-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | XENTION LIMITED (GB) | 2010-03-04 | — | — | WO | claimed |