Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR65 | Q8IYL9 | 8/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 2/20 | 0.41 |
| ▸ | RICTOR | Q6R327 | 2/20 | 0.41 |
| ▸ | MAPKAP1 | Q9BPZ7 | 2/20 | 0.41 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.41 |
| ▸ | CCR2 | P41597 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30390605 | 1.00 | GPR65 (0.52) | GPR65CYP3A4CYP2D6CYP2C19MEN1 | |
| SCHEMBL26879877 | 1.00 | GPR65 (0.52) | GPR65CYP3A4CYP2D6CYP2C19MEN1 | |
| SCHEMBL30390761 | 0.93 | GPR65 (0.53) | GPR65CYP3A4CYP2D6CYP2C19MEN1 | |
| SCHEMBL26879882 | 0.93 | GPR65 (0.53) | GPR65CYP3A4CYP2D6CYP2C19MEN1 | |
| SCHEMBL30390684 | 0.93 | GPR65 (0.53) | GPR65CYP3A4CYP2D6CYP2C19MEN1 | |
| SCHEMBL30390800 | 0.93 | GPR65 (0.53) | GPR65CYP3A4CYP2D6CYP2C19MEN1 | |
| SCHEMBL30390639 | 0.89 | GPR65 (0.49) | GPR65CYP3A4CYP2D6CYP2C19MEN1 | |
| SCHEMBL30391145 | 0.89 | GPR65 (0.49) | GPR65CYP3A4CYP2D6CYP2C19MEN1 | |
| SCHEMBL30390891 | 0.89 | GPR65 (0.49) | GPR65CYP3A4CYP2D6CYP2C19MEN1 | |
| SCHEMBL30390946 | 0.89 | GPR65 (0.47) | GPR65CYP3A4CYP2D6CYP2C19MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4161642-A1 | N-PHENYLAMINOCARBONYL PYRIDINO-, PYRIMIDINO AND BENZO-TROPANES AS MODULATORS OF GPR65 | Pathios Therapeutics Limited (GB) | 2023-04-12 | — | — | EP | disclosed |