GPR65

G-protein coupled receptor 65 · Q8IYL9 · GPR65 on Sugi Atlas →

17,488 patent compounds predicted against GPR65, 14,227 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Salmeterol (SCHEMBL4767)	1.00	1/20
Salmeterol (SCHEMBL4768)	1.00	1/20
Fluoxetine (SCHEMBL33384)	1.00	1/20
Nefazodone (SCHEMBL41119)	1.00	1/20
Fluoxetine (SCHEMBL56333)	1.00	1/20
Cinacalcet (SCHEMBL195640)	1.00	1/20
Niguldipine (SCHEMBL245992)	1.00	1/20
Niguldipine (SCHEMBL245993)	1.00	1/20
Aprepitant (SCHEMBL263983)	1.00	1/20
Aprepitant (SCHEMBL280611)	1.00	1/20
SCHEMBL375979	1.00	1/20
Cp-96345 (SCHEMBL675159)	1.00	1/20
Cp-96345 (SCHEMBL675160)	1.00	1/20
Pimavanserin (SCHEMBL675165)	1.00	1/20
Dexniguldipine (SCHEMBL724137)	1.00	1/20
Tecalcet (SCHEMBL1178446)	1.00	1/20
Tecalcet (SCHEMBL1178449)	1.00	1/20
Cinacalcet (SCHEMBL1179140)	1.00	1/20
Purvalanola (SCHEMBL1217069)	1.00	1/20
Cp-96345 (SCHEMBL1447963)	1.00	1/20

Clinical trials — most relevant to GPR65 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Investigating the Potential Role of Aerosolized Retinoic Acid, a Potent Vitamin A Metabolite for Treating COVID-19 Anosmia and Retinoic Acid Insufficiency .A Novel Approach for Regaining Sense of Smell.	PHASE4	UNKNOWN
Acute Regulation of Intestinal and Hepatic Lipoprotein Production by Glucagon	PHASE4	COMPLETED
A Study to Determine the Effect of CT3001 in Patients With Advanced Solid Tumors	PHASE1/PHASE2	RECRUITING
Mediterranean Diet and Inequality in Early Breast Cancer	PHASE2	RECRUITING
A Series of Pilot Studies to Evaluate the haemoDynamic and mEtabolic Effects oF apelIn aNd rElaxin	PHASE2	UNKNOWN
A Safety and Efficacy Study of Carbidopa-levodopa in Patients With Macular Degeneration	PHASE2	WITHDRAWN
Palmitoylethanolamide for Chronic Inflammatory Pain Conditions	PHASE2	RECRUITING
Role of the Gut Sweet Taste Receptor in the Secretion of Glucagon-like Peptide-1 and Peptide YY	PHASE1	COMPLETED
Role of the Gut Sweet Taste Receptor in the Secretion of Satiation Peptides	PHASE1	COMPLETED
Sweet Taste Receptors and the Secretion of Glucagon-like Peptide-1 and Peptide YY	PHASE1	COMPLETED
Evaluation of Two Radioactive Chemicals to Image mGluR5 Receptors in Brain	PHASE1	COMPLETED
FFAR Agonist on Incretins, Insulin, Lipids and Inflammation	nan	COMPLETED
Dose-response Effect of Pine Nut Oil as a Dual FFA1 and FFA4 Agonist on Glucose Tolerance in Healthy Humans.	nan	COMPLETED
Neutrophil FFA2/GPR43 Receptor Expression in Patients With the Diagnosis of Sepsis	nan	WITHDRAWN
Effect of Dietary Oils as G-protein-coupled Receptor Agonists on Glucose Tolerance	nan	UNKNOWN
-Oleoyl Glycerol is a GPR119 Agonist and Signals GLP-1 Release in Humans.	nan	COMPLETED
Gastroparesis Registry 3	nan	COMPLETED
Hyperlactacidemia in Major Abdominal Surgery and Monocarboxylate Receptors	nan	UNKNOWN
Colonic Propionate, Appetite, and Weight Loss	nan	COMPLETED
Oat Bran and Plasma Lipid and Fecal Bacteria in Coronary Artery Disease Patients	nan	COMPLETED
GPR109A and Parkinson's Disease: Role of Niacin in Outcome Measures	nan	COMPLETED
Gut Microbiota and Modulation of Liver Damage in NAFLD	nan	COMPLETED
The Role of Autoantibodies Against G-protein Coupled Receptors in Obesity	nan	NOT_YET_RECRUITING
Colonic Delivery of DIM and Perilla Oil on Gut Hormones and Food Intake in Obesity	nan	COMPLETED
Effects of Probiotics on Gut Microbiota, Endocannabinoid and Immune Activation and Symptoms of Fatigue in Dancers	nan	COMPLETED
Fat-induced Release of GLP-1 in Humans	nan	COMPLETED
Selective Activation of the Adrenomedullin Receptors in Migraine	nan	NOT_YET_RECRUITING
RCT to Describe the Effects of Colon Delivered Acetate, Propionate and Butyrate on Satiety and Glucose Homeostasis	nan	COMPLETED
PET Imaging of Brain mGluR1 Receptors Using [18F]FIMX	nan	COMPLETED
Investigating Optimal Propionate Delivery to the Colon Using Stable Isotope Labeling	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a GPR65 binder may also engage these)

Protein	Name	Similarity
Q61038	—	1.000	Q61038 →
Q3U507	—	0.995	Q3U507 →
Q9XSD4	—	0.994	Q9XSD4 →
GPR174	Probable G-protein coupled receptor 174	0.992	landscape →
GPR183	G-protein coupled receptor 183	0.990	landscape →
D4A7K7	—	0.989	D4A7K7 →
P32303	—	0.989	P32303 →
Q3U6B2	—	0.989	Q3U6B2 →
Q9Z0Z6	—	0.989	Q9Z0Z6 →
A5PLE7	—	0.989	A5PLE7 →
Q9GK76	—	0.988	Q9GK76 →
P21556	—	0.988	P21556 →
B0UXR0	—	0.987	B0UXR0 →
Q9TTY5	—	0.987	Q9TTY5 →
Q1RMI1	—	0.987	Q1RMI1 →
P79785	—	0.987	P79785 →
Q62035	—	0.987	Q62035 →
P56412	—	0.986	P56412 →
Q95N02	—	0.986	Q95N02 →
CYSLTR2	Cysteinyl leukotriene receptor 2	0.986	landscape →
Q2Y2P0	—	0.986	Q2Y2P0 →
Q8BZR0	—	0.986	Q8BZR0 →
Q0VDU3	—	0.985	Q0VDU3 →
Q96P67	—	0.985	Q96P67 →
P46002	—	0.985	P46002 →
Q9BG77	—	0.985	Q9BG77 →
P35373	—	0.985	P35373 →
PTAFR	Platelet-activating factor receptor	0.985	landscape →
B5X337	—	0.985	B5X337 →
Q924T8	—	0.985	Q924T8 →