Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR65 | Q8IYL9 | 9/20 | 0.49 |
| ▸ | CCR2 | P41597 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | ELOVL6 | Q9H5J4 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30391954 | 1.00 | GPR65 (0.49) | GPR65CCR2KCNH2TSHRRECQL | |
| SCHEMBL26879846 | 1.00 | GPR65 (0.49) | GPR65CCR2KCNH2TSHRRECQL | |
| SCHEMBL30391416 | 0.92 | TSHR (0.52) | GPR65CCR2KCNH2TSHRRECQL | |
| SCHEMBL30391423 | 0.92 | TSHR (0.52) | GPR65CCR2KCNH2TSHRRECQL | |
| SCHEMBL26879847 | 0.92 | TSHR (0.52) | GPR65CCR2KCNH2TSHRRECQL | |
| SCHEMBL30391270 | 0.92 | TSHR (0.52) | GPR65CCR2KCNH2TSHRRECQL | |
| SCHEMBL30390699 | 0.89 | GPR65 (0.48) | GPR65CCR2KCNH2TSHRRECQL | |
| SCHEMBL30391181 | 0.89 | GPR65 (0.48) | GPR65CCR2KCNH2TSHRRECQL | |
| SCHEMBL30391848 | 0.89 | GPR65 (0.48) | GPR65CCR2KCNH2TSHRRECQL | |
| SCHEMBL26879873 | 0.89 | GPR65 (0.48) | GPR65CCR2KCNH2TSHRRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4161642-A1 | N-PHENYLAMINOCARBONYL PYRIDINO-, PYRIMIDINO AND BENZO-TROPANES AS MODULATORS OF GPR65 | Pathios Therapeutics Limited (GB) | 2023-04-12 | — | — | EP | disclosed |