Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 3/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26100287 | 1.00 | FAAH (0.37) | FAAHTYK2PDE4DPOLBAPEX1 | |
| SCHEMBL26510925 | 0.92 | TYK2 (0.37) | TYK2PDE4DMAPTEGFRAURKA | |
| SCHEMBL26099790 | 0.92 | TYK2 (0.37) | TYK2PDE4DMAPTEGFRAURKA | |
| Potassium SCHEMBL30392578 | 0.92 | TYK2 (0.37) | TYK2PDE4DMAPTEGFRAURKA | |
| Potassium Ion SCHEMBL30391293 | 0.91 | TYK2 (0.35) | TYK2PDE4DMAPTEGFRAURKA | |
| Potassium Ion SCHEMBL26098159 | 0.91 | TYK2 (0.35) | TYK2PDE4DMAPTEGFRAURKA | |
| SCHEMBL26100963 | 0.89 | TYK2 (0.40) | TYK2PDE4D | |
| SCHEMBL30392554 | 0.89 | FAAH (0.33) | FAAHTYK2PDE4DPOLBAPEX1 | |
| SCHEMBL26100863 | 0.89 | FAAH (0.33) | FAAHTYK2PDE4DPOLBAPEX1 | |
| SCHEMBL26101565 | 0.88 | TYK2 (0.39) | FAAHTYK2PDE4DAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4423086-A1 | TYK2 DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2024-09-04 | — | — | EP | disclosed |
| WO-2023076161-A1 | TYK2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-05-04 | — | — | WO | disclosed |