Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 7/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.32 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.30 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26098936 | 0.99 | TYK2 (0.34) | TYK2PDE4DPDE1BZAP70KARS1 | |
| SCHEMBL30392519 | 0.99 | TYK2 (0.34) | TYK2PDE4DPDE1BZAP70KARS1 | |
| SCHEMBL26097378 | 0.99 | TYK2 (0.33) | TYK2PDE4DPDE1BZAP70KARS1 | |
| SCHEMBL26101733 | 0.92 | TYK2 (0.35) | TYK2PDE4DPDE1B | |
| SCHEMBL30392414 | 0.92 | TYK2 (0.35) | TYK2PDE4DPDE1B | |
| SCHEMBL30391456 | 0.92 | TYK2 (0.37) | TYK2PDE4DPDE1B | |
| SCHEMBL26100863 | 0.92 | FAAH (0.33) | TYK2PDE4DPDE1B | |
| SCHEMBL30392554 | 0.92 | FAAH (0.33) | TYK2PDE4DPDE1B | |
| SCHEMBL26101583 | 0.92 | TYK2 (0.37) | TYK2PDE4DPDE1B | |
| SCHEMBL30392922 | 0.90 | TYK2 (0.37) | TYK2PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4423086-A1 | TYK2 DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2024-09-04 | — | — | EP | disclosed |
| WO-2023076161-A1 | TYK2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-05-04 | — | — | WO | disclosed |