Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUCY1A1 | Q02108 | 8/20 | 0.63 |
| ▸ | GUCY1B1 | Q02153 | 8/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.59 |
| ▸ | HPGD | P15428 | 6/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 3/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.46 |
| ▸ | TRPC1 | P48995 | 2/20 | 0.45 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.45 |
| ▸ | STIM1 | Q13586 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1782185 | 0.92 | GUCY1A1 (0.64) | GUCY1A1GUCY1B1KDM4EHPGDALDH1A1 | |
| SCHEMBL4004406 | 0.90 | GUCY1A1 (0.62) | GUCY1A1GUCY1B1KDM4EHPGDALDH1A1 | |
| SCHEMBL3030195 | 0.89 | GUCY1A1 (0.65) | GUCY1A1GUCY1B1KDM4EHPGDALDH1A1 | |
| SCHEMBL15168687 | 0.89 | GUCY1A1 (0.60) | GUCY1A1GUCY1B1KDM4EHPGDALDH1A1 | |
| SCHEMBL15168665 | 0.89 | GUCY1A1 (0.60) | GUCY1A1GUCY1B1KDM4EHPGDALDH1A1 | |
| SCHEMBL4000216 | 0.87 | GUCY1A1 (0.53) | GUCY1A1GUCY1B1KDM4EHPGDALDH1A1 | |
| SCHEMBL16555604 | 0.87 | GUCY1A1 (0.62) | GUCY1A1GUCY1B1KDM4EHPGDALDH1A1 | |
| SCHEMBL4003949 | 0.86 | GUCY1A1 (0.65) | GUCY1A1GUCY1B1KDM4EHPGDALDH1A1 | |
| SCHEMBL16555919 | 0.85 | GUCY1A1 (0.58) | GUCY1A1GUCY1B1KDM4EHPGDALDH1A1 | |
| SCHEMBL3997119 | 0.84 | GUCY1A1 (0.56) | GUCY1A1GUCY1B1KDM4EHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401265-B1 | DERIVATIVES OF 1-PYRI(MID)IN-2-YL-PYRAZOLE-4-CARBOXYLIC ACID WHICH ARE USEFUL FOR THERAPY OR PROPHYLAXIS OF CARDIOVASCULAR DISEASES | MERCK SHARP & DOHME (US) | 2016-09-14 | — | — | EP | disclosed |
| US-8507512-B2 | Soluble guanylate cyclase activators | MERCK SHARP & DOHME CORP. (US) | 2013-08-13 | — | — | US | disclosed |
| US-20100216764-A1 | Soluble Guanylate Cyclase Activators | MERCK SHARP & DOHME LLC | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216764-A1 | Soluble Guanylate Cyclase Activators | GUCY1B1, GUCY1A1, GUCY1A2 | GUCY1A1 2/4885GUCY1B1 1/4885KDM4E 1927/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.