Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.36 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.31 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8426336 | 0.85 | ALDH1A1 (0.40) | ALDH1A1LMNATP53MAPTL3MBTL1 | |
| SCHEMBL15014638 | 0.83 | TP53 (0.43) | ALDH1A1TP53L3MBTL1KMT2AKAT8 | |
| SCHEMBL24456475 | 0.83 | TP53 (0.43) | ALDH1A1TP53L3MBTL1KMT2AKAT8 | |
| SCHEMBL10289418 | 0.83 | TP53 (0.43) | ALDH1A1TP53L3MBTL1KMT2AKAT8 | |
| SCHEMBL20706357 | 0.82 | ALDH1A1 (0.38) | ALDH1A1ATAD2CECR2LMNATP53 | |
| SCHEMBL23564481 | 0.82 | ALDH1A1 (0.38) | ALDH1A1ATAD2CECR2LMNATP53 | |
| SCHEMBL27152519 | 0.81 | ALDH1A1 (0.36) | ALDH1A1LMNA | |
| SCHEMBL27152520 | 0.81 | ALDH1A1 (0.36) | ALDH1A1LMNA | |
| SCHEMBL13154401 | 0.79 | EPHX2 (0.39) | ALDH1A1ATAD2CECR2LMNAKMT2A | |
| SCHEMBL24515196 | 0.77 | ALDH1A1 (0.39) | ALDH1A1ATAD2CECR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116096710-A | 4-oxo-3, 4-dihydroquinazolinone compounds for the treatment of BRAF related diseases and disorders | 阿雷生物药品公司 | 2023-05-09 | — | — | CN | disclosed |