SCHEMBL30396374

SCHEMBL30396374

COc1cc2oc(-c3ccc(F)c(F)c3)c(O)c(=O)c2cc1OC

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCB1 P08183 1/20 0.61
MAPT P10636 7/20 0.60
KDM4E B2RXH2 5/20 0.60
CYP3A4 P08684 5/20 0.60
CASP1 P29466 5/20 0.60
CASP7 P55210 5/20 0.60
MEN1 O00255 4/20 0.60
ALDH1A1 P00352 4/20 0.60
KMT2A Q03164 4/20 0.60
ABCG2 Q9UNQ0 3/20 0.60
TP53 P04637 6/20 0.59
HPGD P15428 3/20 0.59
HSD17B10 Q99714 3/20 0.59
LMNA P02545 3/20 0.59
ACHE P22303 3/20 0.59
BACE1 P56817 3/20 0.59
ALOX15 P16050 1/20 0.57
MAPK1 P28482 1/20 0.57
SMN1; SMN2 Q16637 1/20 0.57
RXFP1 Q9HBX9 2/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25222567 1.00 ABCB1 (0.61) ABCB1MAPTKDM4ECYP3A4CASP1
SCHEMBL25204764 0.87 CYP1A1 (0.67) ABCB1MAPTKDM4ECYP3A4CASP1
SCHEMBL30397364 0.87 ABCB1 (0.79) ABCB1MAPTKDM4ECYP3A4CASP1
SCHEMBL25235022 0.87 ABCB1 (0.79) ABCB1MAPTKDM4ECYP3A4CASP1
SCHEMBL25205192 0.85 CYP1A1 (0.67) ABCB1MAPTKDM4ECYP3A4CASP1
SCHEMBL10067898 0.85 ADORA3 (0.71) ABCB1MAPTKDM4ECYP3A4CASP1
SCHEMBL29478212 0.84 ABCB1 (0.70) ABCB1MAPTKDM4ECYP3A4CASP1
SCHEMBL25208596 0.84 CYP1A2 (0.70) ABCB1MAPTKDM4ECYP3A4CASP1
SCHEMBL30397431 0.84 CYP1A2 (0.70) ABCB1MAPTKDM4ECYP3A4CASP1
SCHEMBL25208716 0.84 MAPT (0.65) ABCB1MAPTKDM4ECYP3A4CASP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023090908-A1 NOVEL FLAVONOID DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF METABOLIC DISEASE 고려대학교 세종산학협력단 2023-05-25 WO disclosed