Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 7/20 | 0.49 |
| ▸ | CDK12 | Q9NYV4 | 7/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 6/20 | 0.49 |
| ▸ | CDK9 | P50750 | 6/20 | 0.49 |
| ▸ | CDK7 | P50613 | 5/20 | 0.49 |
| ▸ | CCNH | P51946 | 5/20 | 0.49 |
| ▸ | MNAT1 | P51948 | 5/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.49 |
| ▸ | CDK2 | P24941 | 5/20 | 0.49 |
| ▸ | ULK1 | O75385 | 1/20 | 0.38 |
| ▸ | MAPK3 | P27361 | 9/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25528791 | 0.91 | CDK7 (0.51) | CCNKCDK12CCNT1CDK9CDK7 | |
| SCHEMBL25528804 | 0.87 | CCNK (0.52) | CCNKCDK12CCNT1CDK9CDK7 | |
| SCHEMBL30397416 | 0.86 | CCNK (0.48) | CCNKCDK12CCNT1CDK9CDK7 | |
| SCHEMBL25528330 | 0.86 | CCNK (0.54) | CCNKCDK12CCNT1CDK9CDK7 | |
| SCHEMBL25420227 | 0.85 | CCNK (0.47) | CCNKCDK12CCNT1CDK9CDK7 | |
| SCHEMBL30398138 | 0.85 | CCNK (0.47) | CCNKCDK12CCNT1CDK9CDK7 | |
| SCHEMBL25518487 | 0.85 | CCNK (0.47) | CCNKCDK12CCNT1CDK9CDK7 | |
| SCHEMBL25420224 | 0.85 | CCNK (0.47) | CCNKCDK12CCNT1CDK9CDK7 | |
| SCHEMBL25528708 | 0.84 | CCNK (0.53) | CCNKCDK12CCNT1CDK9CDK7 | |
| SCHEMBL30396054 | 0.84 | CCNK (0.54) | CCNKCDK12CCNT1CDK9CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |