Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 1/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 3/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | MAPK3 | P27361 | 3/20 | 0.33 |
| ▸ | CCNK | O75909 | 2/20 | 0.32 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | CDK7 | P50613 | 1/20 | 0.32 |
| ▸ | CCNH | P51946 | 1/20 | 0.32 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30397129 | 1.00 | ULK1 (0.37) | ULK1PTK2CDK2KDRMAPK3 | |
| SCHEMBL30397777 | 0.92 | ULK1 (0.35) | ULK1PTK2CDK2KDRMAPK3 | |
| SCHEMBL30398187 | 0.92 | ULK1 (0.35) | ULK1PTK2CDK2KDRMAPK3 | |
| SCHEMBL30397660 | 0.91 | MAPK8 (0.37) | ULK1PTK2CDK2KDRMAPK3 | |
| SCHEMBL25522736 | 0.90 | ULK1 (0.37) | ULK1PTK2CDK2KDRCCNK | |
| SCHEMBL25522704 | 0.90 | ULK1 (0.37) | ULK1PTK2CDK2KDRCCNK | |
| SCHEMBL30397675 | 0.90 | ULK1 (0.37) | ULK1PTK2CDK2KDRCCNK | |
| SCHEMBL30397986 | 0.89 | PTK2 (0.34) | ULK1PTK2CDK2KDRMAPK3 | |
| SCHEMBL30398084 | 0.89 | PTK2 (0.34) | ULK1PTK2CDK2KDRMAPK3 | |
| SCHEMBL30397201 | 0.88 | ULK1 (0.36) | ULK1PTK2CDK2KDRCCNK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |