Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.38 |
| ▸ | PIM1 | P11309 | 4/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.36 |
| ▸ | NT5E | P21589 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25417102 | 1.00 | KDM4E (0.53) | KDM4EHSD17B10KMT2AALDH1A1HPGD | |
| SCHEMBL25419836 | 0.82 | KDM4E (0.53) | KDM4EHSD17B10KMT2AALDH1A1HPGD | |
| SCHEMBL30396864 | 0.82 | KDM4E (0.53) | KDM4EHSD17B10KMT2AALDH1A1HPGD | |
| SCHEMBL6219388 | 0.75 | KDM4E (0.73) | KDM4EHSD17B10KMT2AALDH1A1HPGD | |
| SCHEMBL23458576 | 0.74 | KDM4E (0.67) | KDM4EHSD17B10KMT2AALDH1A1HPGD | |
| SCHEMBL25421165 | 0.73 | KDM4E (0.53) | KDM4EHSD17B10KMT2AALDH1A1HPGD | |
| SCHEMBL30498956 | 0.71 | KDM4E (0.58) | KDM4EHSD17B10KMT2AALDH1A1HPGD | |
| SCHEMBL22322737 | 0.70 | KDM4E (0.57) | KDM4EHSD17B10KMT2AALDH1A1HPGD | |
| SCHEMBL30498960 | 0.69 | KDM4E (1.00) | KDM4EHSD17B10KMT2AALDH1A1HPGD | |
| SCHEMBL2021844 | 0.69 | ALDH1A1 (0.43) | KDM4EHSD17B10KMT2AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |