Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.58 |
| ▸ | IL2 | P60568 | 4/20 | 0.58 |
| ▸ | MAP3K11 | Q16584 | 6/20 | 0.47 |
| ▸ | TDO2 | P48775 | 1/20 | 0.46 |
| ▸ | TNIK | Q9UKE5 | 7/20 | 0.43 |
| ▸ | CDK2 | P24941 | 3/20 | 0.43 |
| ▸ | IKBKB | O14920 | 2/20 | 0.43 |
| ▸ | CHUK | O15111 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 2/20 | 0.43 |
| ▸ | INSR | P06213 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | SGK1 | O00141 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26175600 | 1.00 | MAP4K1 (0.58) | MAP4K1IL2MAP3K11TDO2TNIK | |
| SCHEMBL26175638 | 0.90 | IL2 (0.47) | MAP4K1IL2MAP3K11TNIKCDK2 | |
| SCHEMBL26174832 | 0.85 | CLK1 (0.47) | MAP4K1IL2CDK2FLT3ROCK2 | |
| SCHEMBL26175197 | 0.83 | DYRK1A (0.48) | MAP4K1IL2TDO2CLK1DYRK1A | |
| SCHEMBL30400148 | 0.83 | DYRK1A (0.48) | MAP4K1IL2TDO2CLK1DYRK1A | |
| SCHEMBL26177407 | 0.82 | DYRK1A (0.47) | MAP4K1IL2CDK2FLT3ROCK2 | |
| SCHEMBL30399189 | 0.82 | DYRK1A (0.47) | MAP4K1IL2CDK2FLT3ROCK2 | |
| SCHEMBL26175331 | 0.81 | PDPK1 (0.52) | MAPK1 | |
| SCHEMBL26174870 | 0.80 | TNIK (0.50) | MAP4K1MAP3K11TNIKCDK2IKBKB | |
| SCHEMBL26175446 | 0.80 | CCNT1 (0.57) | TNIKCDK2NTRK1CLK1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4415817-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AS DYRK1A INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2024-08-21 | — | — | EP | claimed |
| WO-2023064349-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AS DYRK1A INHIBITORS | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | claimed |