Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 10/20 | 0.48 |
| ▸ | CLK1 | P49759 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | WNT1 | P04628 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | IL2 | P60568 | 1/20 | 0.40 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 2/20 | 0.39 |
| ▸ | CLK3 | P49761 | 2/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26175197 | 1.00 | DYRK1A (0.48) | DYRK1ACLK1RAB9AL3MBTL1SMN1; SMN2 | |
| SCHEMBL30400402 | 0.83 | MAP4K1 (0.58) | DYRK1ACLK1IL2MAP4K1TDO2 | |
| SCHEMBL26175600 | 0.83 | MAP4K1 (0.58) | DYRK1ACLK1IL2MAP4K1TDO2 | |
| SCHEMBL26174957 | 0.82 | MAP3K11 (0.49) | DYRK1ACLK1 | |
| SCHEMBL26175116 | 0.81 | MAPK7 (0.45) | DYRK1ACLK1DYRK1BGSK3BWNT1 | |
| SCHEMBL26174909 | 0.81 | HPGDS (0.41) | DYRK1ADYRK1BWNT1 | |
| SCHEMBL26175220 | 0.81 | RAB9A (0.56) | DYRK1ACLK1RAB9AL3MBTL1SMN1; SMN2 | |
| SCHEMBL30400764 | 0.81 | RAB9A (0.56) | DYRK1ACLK1RAB9AL3MBTL1SMN1; SMN2 | |
| SCHEMBL30399189 | 0.79 | DYRK1A (0.47) | DYRK1ACLK1DYRK1BIL2MAP4K1 | |
| SCHEMBL26177407 | 0.79 | DYRK1A (0.47) | DYRK1ACLK1DYRK1BIL2MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4415817-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AS DYRK1A INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2024-08-21 | — | — | EP | claimed |
| WO-2023064349-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AS DYRK1A INHIBITORS | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | claimed |