Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 3/20 | 0.40 |
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
| ▸ | CLK2 | P49760 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.35 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.35 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.35 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.35 |
| ▸ | CSNK1G3 | Q9Y6M4 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | PAK4 | O96013 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20416801 | 1.00 | PDE4D (0.40) | PDE4DPDE4APDE4BPDE4CKLKB1 | |
| SCHEMBL20401282 | 1.00 | PDE4D (0.40) | PDE4DPDE4APDE4BPDE4CKLKB1 | |
| SCHEMBL20401285 | 1.00 | PDE4D (0.40) | PDE4DPDE4APDE4BPDE4CKLKB1 | |
| SCHEMBL20417084 | 0.92 | KLKB1 (0.39) | PDE4DPDE4APDE4BPDE4CKLKB1 | |
| SCHEMBL20416812 | 0.92 | PDE4D (0.39) | PDE4DPDE4APDE4BPDE4CKLKB1 | |
| SCHEMBL20421974 | 0.92 | PDE4D (0.39) | PDE4DPDE4APDE4BPDE4CKLKB1 | |
| SCHEMBL20416906 | 0.91 | ADORA2A (0.42) | PDE4DPDE4APDE4BPDE4CKLKB1 | |
| SCHEMBL30401928 | 0.91 | ADORA2A (0.42) | PDE4DPDE4APDE4BPDE4CKLKB1 | |
| SCHEMBL20401220 | 0.91 | ADORA2A (0.42) | PDE4DPDE4APDE4BPDE4CKLKB1 | |
| SCHEMBL20401215 | 0.91 | ADORA2A (0.42) | PDE4DPDE4APDE4BPDE4CKLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116768859-A | Azolopyrimidines for the treatment of cancer related disorders | 艾库斯生物科学有限公司 | 2023-09-19 | — | — | CN | disclosed |
| EP-3570844-B1 | AZOLOPYRIMIDINE FOR THE TREATMENT OF CANCER-RELATED DISORDERS | ARCUS BIOSCIENCES INC (US) | 2023-09-06 | — | — | EP | disclosed |
| CN-110214012-B | Azolopyrimidines for the treatment of cancer related disorders | 艾库斯生物科学有限公司 | 2023-05-09 | — | — | CN | disclosed |