Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.43 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.37 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
| ▸ | CLK2 | P49760 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | PAK4 | O96013 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20416863 | 1.00 | NOTUM (0.44) | NOTUMPDE4DPDE4APDE4BPDE4C | |
| SCHEMBL20401302 | 0.95 | PDE4D (0.47) | NOTUMPDE4DPDE4APDE4BPDE4C | |
| SCHEMBL30402083 | 0.90 | NOTUM (0.44) | NOTUMPDE4DPDE4APDE4BPDE4C | |
| SCHEMBL30401203 | 0.90 | NOTUM (0.44) | NOTUMPDE4DPDE4APDE4BPDE4C | |
| SCHEMBL20416789 | 0.90 | NOTUM (0.44) | NOTUMPDE4DPDE4APDE4BPDE4C | |
| SCHEMBL20416790 | 0.90 | NOTUM (0.44) | NOTUMPDE4DPDE4APDE4BPDE4C | |
| SCHEMBL20416785 | 0.90 | NOTUM (0.44) | NOTUMPDE4DPDE4APDE4BPDE4C | |
| SCHEMBL30401568 | 0.90 | NOTUM (0.44) | NOTUMPDE4DPDE4APDE4BPDE4C | |
| SCHEMBL20417123 | 0.86 | DGAT2 (0.42) | NOTUMPDE4DPDE4APDE4BPDE4C | |
| SCHEMBL30401861 | 0.86 | DGAT2 (0.42) | NOTUMPDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116768859-A | Azolopyrimidines for the treatment of cancer related disorders | 艾库斯生物科学有限公司 | 2023-09-19 | — | — | CN | disclosed |
| CN-110214012-B | Azolopyrimidines for the treatment of cancer related disorders | 艾库斯生物科学有限公司 | 2023-05-09 | — | — | CN | disclosed |