Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.80 |
| ▸ | KDM4E | B2RXH2 | 13/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.67 |
| ▸ | NPC1 | O15118 | 7/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.67 |
| ▸ | RAB9A | P51151 | 7/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.65 |
| ▸ | HTT | P42858 | 1/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 7/20 | 0.57 |
| ▸ | POLB | P06746 | 3/20 | 0.57 |
| ▸ | USP2 | O75604 | 2/20 | 0.57 |
| ▸ | ESR1 | P03372 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | TP53 | P04637 | 4/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17541563 | 1.00 | TSHR (0.80) | TSHRKDM4EALDH1A1NPC1MAPK1 | |
| SCHEMBL17544428 | 0.86 | TSHR (0.80) | TSHRKDM4EALDH1A1NPC1MAPK1 | |
| SCHEMBL30402341 | 0.86 | TSHR (0.80) | TSHRKDM4EALDH1A1NPC1MAPK1 | |
| SCHEMBL25795646 | 0.85 | KDM4E (1.00) | TSHRKDM4EALDH1A1NPC1MAPK1 | |
| SCHEMBL14338225 | 0.84 | SMN1; SMN2 (0.60) | TSHRKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL30402936 | 0.82 | KDM4E (0.70) | TSHRKDM4EALDH1A1NPC1MAPK1 | |
| SCHEMBL17544230 | 0.82 | KDM4E (0.70) | TSHRKDM4EALDH1A1NPC1MAPK1 | |
| SCHEMBL19428488 | 0.81 | KDM4E (0.79) | TSHRKDM4EALDH1A1NPC1MAPK1 | |
| SCHEMBL17544222 | 0.79 | TSHR (0.64) | TSHRKDM4EALDH1A1NPC1MAPK1 | |
| SCHEMBL30402997 | 0.79 | TSHR (0.64) | TSHRKDM4EALDH1A1NPC1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116655618-A | Probes for imaging huntingtin | CHDI基金会股份有限公司 | 2023-08-29 | — | — | CN | disclosed |
| CN-107108534-B | Probes for imaging huntingtin | CHDI基金会股份有限公司 | 2023-05-09 | — | — | CN | disclosed |