Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 12/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.76 |
| ▸ | NPC1 | O15118 | 5/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.76 |
| ▸ | TSHR | P16473 | 2/20 | 0.73 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.65 |
| ▸ | HPGD | P15428 | 6/20 | 0.65 |
| ▸ | POLB | P06746 | 3/20 | 0.65 |
| ▸ | USP2 | O75604 | 1/20 | 0.65 |
| ▸ | ESR1 | P03372 | 1/20 | 0.65 |
| ▸ | HPSE | Q9Y251 | 3/20 | 0.61 |
| ▸ | RAB9A | P51151 | 5/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2434363 | 0.90 | KDM4E (0.82) | KDM4EALDH1A1NPC1MAPK1TSHR | |
| SCHEMBL19428488 | 0.89 | KDM4E (0.79) | KDM4EALDH1A1NPC1MAPK1TSHR | |
| SCHEMBL507169 | 0.87 | KDM4E (0.77) | KDM4EALDH1A1NPC1MAPK1HPGD | |
| SCHEMBL30401752 | 0.85 | TSHR (0.80) | KDM4EALDH1A1NPC1MAPK1TSHR | |
| SCHEMBL17541563 | 0.85 | TSHR (0.80) | KDM4EALDH1A1NPC1MAPK1TSHR | |
| SCHEMBL24449082 | 0.84 | KDM4E (0.72) | KDM4EALDH1A1NPC1MAPK1TSHR | |
| SCHEMBL17544366 | 0.83 | KDM4E (0.71) | KDM4EALDH1A1NPC1MAPK1TSHR | |
| SCHEMBL29681116 | 0.83 | KDM4E (0.71) | KDM4EALDH1A1NPC1MAPK1TSHR | |
| SCHEMBL23633316 | 0.82 | KDM4E (0.74) | KDM4EALDH1A1NPC1MAPK1TSHR | |
| SCHEMBL17544428 | 0.82 | TSHR (0.80) | KDM4EALDH1A1NPC1MAPK1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230212190-A1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION, INC. | 2023-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230212190-A1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | HTT, HYPK, HSPBP1 | KDM4E 4585/4885ALDH1A1 3976/4885NPC1 163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.