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Formic Acid

Formic Acid

SCHEMBL30402623

CC(C#N)Oc1ccc(-c2cnc3c(Nc4ccc(C(=O)NCCN5CCNCC5)c(Cl)c4)nccn23)c(F)c1F.O=CO

nearest known ligand 0.45

Full drug profile on Sugi Atlas →

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ PTK6 Q13882 14/20 0.45
▸ LCK P06239 6/20 0.36
▸ AURKB Q96GD4 4/20 0.36
▸ EGFR P00533 4/20 0.35
▸ ERBB2 P04626 3/20 0.35
▸ EIF4E P06730 1/20 0.35
▸ MKNK1 Q9BUB5 1/20 0.35
▸ MKNK2 Q9HBH9 1/20 0.35
▸ HTR4 Q13639 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Formic Acid SCHEMBL22123801 1.00 PTK6 (0.45) PTK6LCKAURKBEGFRERBB2
SCHEMBL22123327 0.98 PTK6 (0.47) PTK6LCKAURKBEGFRERBB2
SCHEMBL22122928 0.88 PTK6 (0.51) PTK6LCKAURKBEGFRERBB2
SCHEMBL30171940 0.88 PTK6 (0.51) PTK6LCKAURKBEGFRERBB2
SCHEMBL22123492 0.88 PTK6 (0.39) PTK6LCKEGFRERBB2
SCHEMBL22123687 0.87 PTK6 (0.48) PTK6LCKAURKBEGFRERBB2
SCHEMBL22123032 0.85 PTK6 (0.48) PTK6LCKAURKBEGFRERBB2
Formic Acid SCHEMBL30171541 0.84 PTK6 (0.46) PTK6LCKAURKB
SCHEMBL30183416 0.84 PTK6 (0.50) PTK6LCKAURKBEGFRERBB2
SCHEMBL30402648 0.83 PTK6 (0.47) PTK6LCKAURKBEGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3898630-B1 NOVEL IMIDAZOPYRAZINE DERIVATIVES HOFFMANN LA ROCHE (CH) 2023-05-10 — — EP disclosed
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