SCHEMBL3040264

SCHEMBL3040264

Nc1ccc(-c2cccc3cnccc23)cc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRKCZ Q05513 2/20 0.65
LMNA P02545 1/20 0.58
CYP1A2 P05177 1/20 0.58
CYP3A4 P08684 1/20 0.58
CYP2D6 P10635 1/20 0.58
CYP2C9 P11712 1/20 0.58
CYP2C19 P33261 1/20 0.58
TNF P01375 2/20 0.53
KDM4E B2RXH2 1/20 0.49
MAPKAPK2 P49137 1/20 0.49
IKBKE Q14164 1/20 0.47
TBK1 Q9UHD2 1/20 0.47
HTT P42858 1/20 0.45
EPHX2 P34913 1/20 0.43
IMPDH2 P12268 2/20 0.42
KDR P35968 2/20 0.41
PIK3CD O00329 1/20 0.41
PIK3CB P42338 1/20 0.41
PIK3CG P48736 1/20 0.41
BACE1 P56817 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17945845 0.85 TNF (0.51) PRKCZLMNACYP1A2CYP3A4CYP2D6
SCHEMBL4513775 0.85 CYP3A4 (0.56) PRKCZLMNACYP1A2CYP3A4CYP2D6
SCHEMBL12074747 0.84 TNF (0.69) PRKCZLMNACYP1A2CYP3A4CYP2D6
SCHEMBL6998015 0.84 TNF (0.73) PRKCZLMNACYP1A2CYP3A4CYP2D6
SCHEMBL17945511 0.83 TNF (0.63) PRKCZLMNACYP1A2CYP3A4CYP2D6
SCHEMBL1773382 0.83 KDM4E (0.58) PRKCZLMNACYP1A2CYP3A4CYP2D6
SCHEMBL7118474 0.83 CYP17A1 (0.55) PRKCZLMNACYP1A2CYP3A4CYP2D6
SCHEMBL12386959 0.83 TNF (0.53) PRKCZLMNACYP1A2CYP3A4CYP2D6
SCHEMBL25454970 0.82 LMNA (0.53) PRKCZLMNACYP1A2CYP3A4CYP2D6
SCHEMBL20095043 0.82 KDR (0.56) PRKCZLMNACYP1A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12351822-B2 Stem cell culture systems for columnar epithelial stem cells, and uses related thereto UNIVERSITY OF HOUSTON SYSTEM (US) 2025-07-08 US disclosed
US-20230372515-A1 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CANCERS ASSOCIATED WITH ACTIVATION OF THE MAPK PATHWAY INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) 2023-11-23 US disclosed
US-20230357714-A1 STEM CELL CULTURE SYSTEMS FOR COLUMNAR EPITHELIAL STEM CELLS, AND USES RELATED THERETO UNIVERSITY OF HOUSTON SYSTEM (US) 2023-11-09 US disclosed
US-11725185-B2 Stem cell culture systems for columnar epithelial stem cells, and uses related thereto UNIVERSITY OF HOUSTON SYSTEM (US) 2023-08-15 US disclosed
US-11471538-B2 Methods and pharmaceutical compositions for the treatment of cancers associated with activation of the MAPK pathway INSERM (Institut National de la Santéet de la Recherche Medicale) (FR) 2022-10-18 US disclosed
US-20210062145-A1 STEM CELL CULTURE SYSTEMS FOR COLUMNAR EPITHELIAL STEM CELLS, AND USES RELATED THERETO UNIVERSITY OF HOUSTON SYSTEM (US) 2021-03-04 US disclosed
EP-3732285-A1 STEM CELL CULTURE SYSTEMS FOR COLUMNAR EPITHELIAL STEM CELLS, AND USES RELATED THERETO Tract Pharmaceuticals, Inc. (US) 2020-11-04 EP disclosed
US-20190262343-A1 WOUND HEALING USING BRAF INHIBITORS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2019-08-29 US disclosed
EP-3471701-A1 WOUND HEALING USING BRAF INHIBITORS The Regents of the University of California (US) 2019-04-24 EP disclosed
WO-2018146253-A1 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CANCERS ASSOCIATED WITH ACTIVATION OF THE MAPK PATHWAY INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) 2018-08-16 WO disclosed
WO-2010032986-A3 NOVEL 5-(4-AMINOPHENYL)-ISOQUINOLINE DERIVATIVE, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PRODUCTION METHOD FOR SAME, AND COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PROPHYLAXIS AND TREATMENT OF MEDICAL CONDITION INDUCED BY RAF KINASE HYPERACTIVITY 주식회사 이큐스팜 (KR) 2010-08-19 WO disclosed
WO-2010032986-A2 NOVEL 5-(4-AMINOPHENYL)-ISOQUINOLINE DERIVATIVE, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PRODUCTION METHOD FOR SAME, AND COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PROPHYLAXIS AND TREATMENT OF MEDICAL CONDITION INDUCED BY RAF KINASE HYPERACTIVITY 주식회사 이큐스팜 (KR) 2010-03-25 WO disclosed
WO-2010032986-A2 NOVEL 5-(4-AMINOPHENYL)-ISOQUINOLINE DERIVATIVE, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PRODUCTION METHOD FOR SAME, AND COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PROPHYLAXIS AND TREATMENT OF MEDICAL CONDITION INDUCED BY RAF KINASE HYPERACTIVITY 주식회사 이큐스팜 (KR) 2010-03-25 WO disclosed
WO-2010032986-A2 NOVEL 5-(4-AMINOPHENYL)-ISOQUINOLINE DERIVATIVE, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PRODUCTION METHOD FOR SAME, AND COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PROPHYLAXIS AND TREATMENT OF MEDICAL CONDITION INDUCED BY RAF KINASE HYPERACTIVITY 주식회사 이큐스팜 (KR) 2010-03-25 WO disclosed
US-20090291949-A1 SUBSTITUTE ISOQUINOLINES USEFUL IN THE TREATMENT OF DISEASES SUCH AS CANCER AND ATHEROSCLEROSIS GLAXO GROUP LIMITED (GB) 2009-11-26 US disclosed
US-20090291949-A1 SUBSTITUTE ISOQUINOLINES USEFUL IN THE TREATMENT OF DISEASES SUCH AS CANCER AND ATHEROSCLEROSIS GLAXO GROUP LIMITED (GB) 2009-11-26 US disclosed
US-20090291949-A1 SUBSTITUTE ISOQUINOLINES USEFUL IN THE TREATMENT OF DISEASES SUCH AS CANCER AND ATHEROSCLEROSIS GLAXO GROUP LIMITED (GB) 2009-11-26 US disclosed
EP-1689717-B1 SUBSTITUTED ISOQUINOLINES USEFUL IN THE TREATMENT OF DISEASES SUCH AS CANCER AND ATHEROSCLEROSIS GLAXO GROUP LTD (GB) 2007-12-26 EP disclosed
EP-1689717-A1 SUBSTITUTED ISOQUINOLINES USEFUL IN THE TREATMENT OF DISEASES SUCH AS CANCER AND ATHEROSCLEROSIS GLAXO GROUP LIMITED (GB) 2006-08-16 EP disclosed
WO-2005049576-A1 SUBSTITUTE ISOQUINOLINES USEFUL IN THE TREATMENT OF DISEASES SUCH AS CANCER AND ATHEROSCLEROSIS GLAXO GROUP LIMITED (GB) 2005-06-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190262343-A1 WOUND HEALING USING BRAF INHIBITORS BRAF, NRAS, RAF1 PRKCZ 1822/4885LMNA 4510/4885CYP1A2 3539/4885
US-20090291949-A1 SUBSTITUTE ISOQUINOLINES USEFUL IN THE TREATMENT OF DISEASES SUCH AS CANCER AND ATHEROSCLEROSIS HRH4, NR1H2, NR1H3 PRKCZ 4826/4885LMNA 1950/4885CYP1A2 1022/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.