Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 13/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 12/20 | 0.56 |
| ▸ | MTOR | P42345 | 10/20 | 0.56 |
| ▸ | ATR | Q13535 | 5/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.54 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.47 |
| ▸ | FECH | P22830 | 1/20 | 0.47 |
| ▸ | CLK1 | P49759 | 1/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | MELK | Q14680 | 1/20 | 0.47 |
| ▸ | MYLK3 | Q32MK0 | 1/20 | 0.47 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.47 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.47 |
| ▸ | TP53RK | Q96S44 | 1/20 | 0.47 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.46 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23634688 | 0.84 | ATM (0.41) | ATMPIK3CAMTORATRPIK3CD | |
| SCHEMBL19618854 | 0.84 | ATM (0.65) | ATMPIK3CAMTORATRPIK3CD | |
| SCHEMBL19346438 | 0.84 | ATM (0.62) | ATMPIK3CAMTORATRPIK3CD | |
| SCHEMBL18114217 | 0.79 | ACVR1 (0.58) | ATMPIK3CAMTORATRPIK3CD | |
| SCHEMBL16748222 | 0.78 | MTOR (0.56) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL16748224 | 0.75 | GABRA1 (0.49) | — | |
| SCHEMBL21913359 | 0.75 | MTOR (0.36) | ATMPIK3CAMTORATRPIK3CD | |
| SCHEMBL18844674 | 0.75 | ATM (0.64) | ATMPIK3CAMTORATRPIK3CD | |
| SCHEMBL21913411 | 0.74 | ATM (0.38) | ATMPIK3CAMTORATR | |
| SCHEMBL18114245 | 0.74 | PRMT5 (0.44) | ATMPIK3CAMTORATRPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4168002-A1 | METHODS FOR DELAYING, PREVENTING, AND TREATING ACQUIRED RESISTANCE TO RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2023-04-26 | — | — | EP | disclosed |