Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 10/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.56 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.56 |
| ▸ | PRKDC | P78527 | 7/20 | 0.56 |
| ▸ | MTOR | P42345 | 10/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.55 |
| ▸ | BTK | Q06187 | 2/20 | 0.51 |
| ▸ | ABL1 | P00519 | 3/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | HCK | P08631 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.49 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.49 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30363757 | 0.85 | MTOR (0.74) | PIK3CDPIK3CGPIK3CAPIK3CBPRKDC | |
| SCHEMBL21527964 | 0.85 | MTOR (0.74) | PIK3CDPIK3CGPIK3CAPIK3CBPRKDC | |
| SCHEMBL30353302 | 0.82 | MTOR (0.54) | PIK3CDPIK3CGPIK3CAPIK3CBPRKDC | |
| SCHEMBL30277454 | 0.79 | BTK (0.69) | PIK3CDPIK3CGPIK3CAPIK3CBPRKDC | |
| SCHEMBL19299699 | 0.78 | PIK3CD (0.62) | PIK3CDPIK3CGPIK3CAPIK3CBPRKDC | |
| Trifluoroacetic Acid SCHEMBL29669759 | 0.78 | MTOR (0.71) | PIK3CDPIK3CGPIK3CAPIK3CBPRKDC | |
| Trifluoroacetic Acid SCHEMBL20552928 | 0.78 | MTOR (0.71) | PIK3CDPIK3CGPIK3CAPIK3CBPRKDC | |
| SCHEMBL30405342 | 0.77 | MTOR (0.43) | PIK3CDPIK3CGPIK3CAPIK3CBPRKDC | |
| SCHEMBL25678062 | 0.76 | MTOR (0.73) | PIK3CDPIK3CGPIK3CAPIK3CBPRKDC | |
| SCHEMBL19294557 | 0.75 | MTOR (0.71) | PIK3CDPIK3CGPIK3CAPIK3CBPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4168002-A1 | METHODS FOR DELAYING, PREVENTING, AND TREATING ACQUIRED RESISTANCE TO RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2023-04-26 | — | — | EP | disclosed |