Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 11/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.41 |
| ▸ | PRKDC | P78527 | 5/20 | 0.41 |
| ▸ | ABL1 | P00519 | 3/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | HCK | P08631 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.41 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.40 |
| ▸ | BTK | Q06187 | 3/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21528183 | 0.89 | MTOR (0.56) | MTORHDAC1PIK3CGPIK3CDPIK3CA | |
| SCHEMBL30578964 | 0.89 | MTOR (0.56) | MTORHDAC1PIK3CGPIK3CDPIK3CA | |
| SCHEMBL25678259 | 0.83 | MTOR (0.55) | MTORHDAC1PIK3CGPIK3CDPIK3CA | |
| SCHEMBL21528092 | 0.80 | MTOR (0.57) | MTORHDAC1PIK3CGPIK3CDPIK3CA | |
| SCHEMBL28517565 | 0.80 | MTOR (0.55) | MTORHDAC1PIK3CGPIK3CDPIK3CA | |
| SCHEMBL30405300 | 0.77 | PIK3CD (0.56) | MTORHDAC1PIK3CGPIK3CDPIK3CA | |
| SCHEMBL23251827 | 0.77 | MTOR (0.51) | MTORHDAC1PIK3CGPIK3CDPIK3CA | |
| SCHEMBL29669781 | 0.76 | MTOR (0.53) | MTORHDAC1PIK3CGPIK3CDPIK3CA | |
| SCHEMBL23251647 | 0.76 | MTOR (0.53) | MTORHDAC1PIK3CGPIK3CDPIK3CA | |
| SCHEMBL25903766 | 0.74 | MTOR (0.41) | MTORHDAC1PIK3CGPIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4168002-A1 | METHODS FOR DELAYING, PREVENTING, AND TREATING ACQUIRED RESISTANCE TO RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2023-04-26 | — | — | EP | disclosed |