Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 7/20 | 0.54 |
| ▸ | SRC | P12931 | 4/20 | 0.54 |
| ▸ | LCK | P06239 | 3/20 | 0.54 |
| ▸ | KDR | P35968 | 2/20 | 0.54 |
| ▸ | CDC7 | O00311 | 1/20 | 0.54 |
| ▸ | PLK4 | O00444 | 1/20 | 0.54 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.54 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.54 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.54 |
| ▸ | INSR | P06213 | 1/20 | 0.54 |
| ▸ | FYN | P06241 | 1/20 | 0.54 |
| ▸ | CDK1 | P06493 | 1/20 | 0.54 |
| ▸ | RET | P07949 | 1/20 | 0.54 |
| ▸ | ROS1 | P08922 | 1/20 | 0.54 |
| ▸ | FER | P16591 | 1/20 | 0.54 |
| ▸ | PRKACA | P17612 | 1/20 | 0.54 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.54 |
| ▸ | CDK2 | P24941 | 1/20 | 0.54 |
| ▸ | MARK3 | P27448 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30353312 | 0.87 | JAK3 (0.50) | JAK2LCKJAK3JAK1FGFR2 | |
| SCHEMBL30405165 | 0.83 | FGFR1 (0.49) | JAK2JAK3JAK1FGFR2FGFR1 | |
| SCHEMBL29503478 | 0.82 | SRC (0.58) | JAK2SRCLCKKDRCDC7 | |
| SCHEMBL2965560 | 0.82 | SRC (0.58) | JAK2SRCLCKKDRCDC7 | |
| SCHEMBL5821932 | 0.82 | JAK2 (0.53) | JAK2SRCLCKKDRCDC7 | |
| SCHEMBL29845637 | 0.81 | JAK2 (0.55) | JAK2SRCLCKKDRPLK4 | |
| SCHEMBL12253480 | 0.81 | JAK2 (0.66) | JAK2SRCLCKKDRCDC7 | |
| SCHEMBL5802940 | 0.81 | JAK2 (0.60) | JAK2SRCLCKKDRCDC7 | |
| SCHEMBL5802174 | 0.80 | JAK2 (0.67) | JAK2SRCLCKKDRCDC7 | |
| SCHEMBL30561442 | 0.79 | ADK (0.46) | JAK2SRCLCKKDRCDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4168002-A1 | METHODS FOR DELAYING, PREVENTING, AND TREATING ACQUIRED RESISTANCE TO RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2023-04-26 | — | — | EP | disclosed |