Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | IKBKB | O14920 | 9/20 | 0.48 |
| ▸ | PBK | Q96KB5 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.47 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3043463 | 0.96 | SCN9A (0.51) | SCN9AHDAC4HDAC6IKBKBCYP1A2 | |
| SCHEMBL3760743 | 0.86 | ADRB1 (0.59) | SCN9AHDAC4HDAC6IKBKBPBK | |
| SCHEMBL6221703 | 0.86 | ADRB1 (0.59) | SCN9AHDAC4HDAC6IKBKBPBK | |
| SCHEMBL20344080 | 0.84 | SCN9A (0.60) | SCN9AHDAC4HDAC6IKBKBPBK | |
| SCHEMBL17888386 | 0.83 | SCN9A (0.58) | SCN9AHDAC4HDAC6IKBKBPBK | |
| SCHEMBL3037871 | 0.83 | SCN9A (0.58) | SCN9AHDAC4HDAC6IKBKBPBK | |
| SCHEMBL6221784 | 0.83 | SCN9A (0.61) | SCN9AHDAC4HDAC6IKBKBPBK | |
| SCHEMBL6221777 | 0.83 | SCN9A (0.61) | SCN9AHDAC4HDAC6IKBKBPBK | |
| SCHEMBL6226816 | 0.83 | SCN9A (0.61) | SCN9AHDAC4HDAC6IKBKBPBK | |
| SCHEMBL20344016 | 0.83 | SCN9A (0.58) | SCN9AHDAC4HDAC6IKBKBPBK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100216791-A1 | PYRIDINYLQUINAZOLINAMINE DERIVATIVES AND THEIR USE AS B-RAF INHIBITORS | ASTRAZENECA (SE) | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216791-A1 | PYRIDINYLQUINAZOLINAMINE DERIVATIVES AND THEIR USE AS B-RAF INHIBITORS | BRAF, RAF1, ARAF | SCN9A 3323/4885HDAC4 3638/4885HDAC6 3050/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.