Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 5/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | F12 | P00748 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL745498 | 1.00 | OPRM1 (0.49) | OPRM1OPRD1OPRK1OPRL1SLC6A2 | |
| SCHEMBL24455261 | 0.86 | OPRM1 (0.60) | OPRM1OPRD1OPRK1OPRL1SLC6A2 | |
| SCHEMBL536557 | 0.81 | OPRM1 (0.53) | OPRM1OPRD1OPRK1OPRL1SLC6A2 | |
| SCHEMBL29460900 | 0.80 | GRIN1 (0.37) | OPRM1OPRD1OPRK1OPRL1SLC6A2 | |
| SCHEMBL17443870 | 0.80 | GRIN1 (0.37) | OPRM1OPRD1OPRK1OPRL1SLC6A2 | |
| SCHEMBL11920692 | 0.80 | OPRM1 (0.40) | OPRM1OPRD1OPRK1SLC6A2 | |
| SCHEMBL4324002 | 0.79 | PDE10A (0.36) | OPRM1OPRD1OPRK1OPRL1PDE10A | |
| SCHEMBL745489 | 0.79 | PDE10A (0.31) | OPRM1OPRL1F12PDE10AALDH1A1 | |
| SCHEMBL743725 | 0.79 | OPRM1 (0.37) | OPRM1OPRD1OPRK1OPRL1ALDH1A1 | |
| SCHEMBL29980665 | 0.78 | OPRM1 (0.57) | OPRM1OPRD1OPRK1OPRL1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023081666-A1 | COMPOUNDS AS CCR2 MODULATORS | ARIA PHARMACEUTICALS, INC. (US) | 2023-05-11 | — | — | WO | disclosed |