Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 14/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24216585 | 1.00 | HDAC6 (0.42) | HDAC6HDAC1PSEN1PSEN2KCNH2 | |
| SCHEMBL25351960 | 0.88 | HDAC6 (0.43) | HDAC6HDAC1 | |
| SCHEMBL25350779 | 0.82 | HDAC6 (0.58) | HDAC6HDAC1 | |
| SCHEMBL24215834 | 0.82 | HDAC1 (0.48) | HDAC6HDAC1 | |
| SCHEMBL30409440 | 0.82 | HDAC1 (0.48) | HDAC6HDAC1 | |
| SCHEMBL25992738 | 0.81 | TEK (0.47) | HDAC6HDAC1 | |
| SCHEMBL25351646 | 0.81 | DPP4 (0.48) | HDAC6HDAC1 | |
| SCHEMBL30409969 | 0.81 | HDAC1 (0.51) | HDAC6HDAC1 | |
| SCHEMBL25350410 | 0.81 | HDAC6 (0.45) | HDAC6HDAC1 | |
| SCHEMBL24215788 | 0.81 | HDAC1 (0.42) | HDAC6HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4185586-A1 | NOVEL COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | Chong Kun Dang Pharmaceutical Corp. (KR) | 2023-05-31 | — | — | EP | disclosed |
| CN-116133658-A | Novel compounds as inhibitors of histone deacetylase 6 and pharmaceutical compositions comprising the same | 株式会社 钟根堂 | 2023-05-16 | — | — | CN | disclosed |