Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 6/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.32 |
| ▸ | MEN1 | O00255 | 4/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30411359 | 0.78 | KDM4E (0.41) | MAPTALDH1A1RAB9AKDM4EKMT2A | |
| SCHEMBL30309821 | 0.76 | NPC1 (0.44) | POLBMAPTALDH1A1RAB9ACRHR1 | |
| SCHEMBL30410437 | 0.74 | ALDH1A1 (0.39) | POLBMAPTALDH1A1RAB9APDK1 | |
| SCHEMBL25414951 | 0.69 | PDE11A (0.36) | POLBALDH1A1CRHR1KDM4EKMT2A | |
| SCHEMBL30184314 | 0.64 | NPC1 (0.43) | MAPTALDH1A1RAB9AKDM4ETDP1 | |
| SCHEMBL16619826 | 0.63 | PIK3CD (0.44) | POLBMAPTALDH1A1RAB9AKDM4E | |
| SCHEMBL29112569 | 0.63 | SMN1; SMN2 (0.46) | POLBMAPTALDH1A1RAB9AKDM4E | |
| SCHEMBL28928898 | 0.62 | POLB (0.44) | POLBMAPTALDH1A1CRHR1TDP1 | |
| SCHEMBL30410851 | 0.60 | KDR (0.44) | MAPTALDH1A1RAB9AKDM4ENPC1 | |
| SCHEMBL30411285 | 0.59 | SCD (0.36) | ALDH1A1KDM4ETDP1ALKBH1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023078267-A1 | AMINO-CONTAINING MACROCYCLIC COMPOUND AS PROTEIN KINASE MODULATOR | 赛诺哈勃药业（成都）有限公司 | 2023-05-11 | — | — | WO | disclosed |