Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL1B | P01584 | 20/20 | 0.41 |
| ▸ | TNF | P01375 | 4/20 | 0.35 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26439816 | 0.66 | IL1B (0.46) | IL1BTNFNLRP3 | |
| SCHEMBL30994049 | 0.65 | IL1B (0.47) | IL1BTNFNLRP3 | |
| SCHEMBL31624721 | 0.64 | IL1B (0.38) | IL1BTNFNLRP3 | |
| SCHEMBL31048131 | 0.63 | IL1B (0.37) | IL1BTNFNLRP3 | |
| SCHEMBL22695045 | 0.63 | IL1B (0.61) | IL1BTNFNLRP3 | |
| SCHEMBL26094347 | 0.62 | IL1B (0.42) | IL1BTNFNLRP3 | |
| SCHEMBL31233716 | 0.61 | IL1B (0.51) | IL1BTNFNLRP3 | |
| SCHEMBL24695709 | 0.60 | IL1B (0.51) | IL1BTNFNLRP3 | |
| SCHEMBL22655138 | 0.60 | IL1B (0.57) | IL1BTNFNLRP3 | |
| SCHEMBL22695042 | 0.60 | IL1B (0.57) | IL1BTNFNLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4419532-A1 | FUSED BICYCLIC HETEROARYL COMPOUNDS USEFUL AS NLRP3 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2024-08-28 | — | — | EP | disclosed |
| WO-2023066825-A1 | FUSED BICYCLIC HETEROARYL COMPOUNDS USEFUL AS NLRP3 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-04-27 | — | — | WO | disclosed |