Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.34 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.34 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28618108 | 0.77 | RECQL (0.41) | RECQLKMOCYP1A2ADRA2AADRA2B | |
| SCHEMBL11217292 | 0.70 | POLB (0.41) | RECQLKMODDB1CRBNCYP1A2 | |
| SCHEMBL1191487 | 0.70 | MEN1 (0.40) | RECQLCA12CA9GAACA1 | |
| SCHEMBL31491641 | 0.68 | DDB1 (0.40) | RECQLKMODDB1CRBNCYP1A2 | |
| Hydrochloric Acid SCHEMBL22609486 | 0.67 | DDB1 (0.40) | RECQLKMODDB1CRBNCYP1A2 | |
| SCHEMBL276288 | 0.66 | RECQL (0.48) | RECQLKMODDB1CRBNCYP1A2 | |
| SCHEMBL5215315 | 0.66 | RECQL (0.41) | RECQLKMODDB1CRBNCYP1A2 | |
| SCHEMBL29521056 | 0.66 | RECQL (0.41) | RECQLKMODDB1CRBNCYP1A2 | |
| SCHEMBL10500232 | 0.66 | RECQL (0.41) | RECQLKMODDB1CRBNCYP1A2 | |
| SCHEMBL27864821 | 0.66 | RECQL (0.38) | RECQLKMODDB1CRBNCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4178954-A1 | SUBSTITUTED PYRROLIDINE AMINES AND AMIDES AS MEDIATOR OF THE GLUCOCORTOID RECEPTOR | Grünenthal GmbH (DE) | 2023-05-17 | — | — | EP | claimed |
| EP-4178954-A1 | SUBSTITUTED PYRROLIDINE AMINES AND AMIDES AS MEDIATOR OF THE GLUCOCORTOID RECEPTOR | Grünenthal GmbH (DE) | 2023-05-17 | — | — | EP | disclosed |