Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | TFPI2 | P48307 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10500232 | 0.96 | RECQL (0.41) | RECQLCYP1A2ADRA2AADRA2BADRA2C | |
| SCHEMBL29521056 | 0.96 | RECQL (0.41) | RECQLCYP1A2ADRA2AADRA2BADRA2C | |
| SCHEMBL9833133 | 0.94 | RECQL (0.40) | RECQLCYP1A2ADRA2AADRA2BADRA2C | |
| SCHEMBL29521086 | 0.84 | HTR2C (0.41) | RECQLCYP1A2ADRA2AADRA2BADRA2C | |
| SCHEMBL29520731 | 0.84 | RECQL (0.38) | RECQLCYP1A2ADRA2AADRA2BADRA2C | |
| SCHEMBL29520805 | 0.84 | LRRK2 (0.47) | RECQLPOLBLRRK2TSHRNPSR1 | |
| SCHEMBL8470553 | 0.84 | HTR2C (0.41) | RECQLCYP1A2ADRA2AADRA2BADRA2C | |
| Hydrochloric Acid SCHEMBL10583863 | 0.82 | ADRA2A (0.41) | RECQLCYP1A2ADRA2AADRA2BADRA2C | |
| SCHEMBL31190755 | 0.77 | RECQL (0.38) | RECQLCYP1A2ADRA2AADRA2BADRA2C | |
| SCHEMBL4788217 | 0.73 | ADRA2A (0.38) | RECQLCYP1A2ADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116262739-A | Nitrogen-containing aryl derivative regulator, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2023-06-16 | — | — | CN | disclosed |
| EP-1753763-A2 | INDAZOLE AND INDOLONE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | Pfizer Limited (GB) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005116027-A2 | INDAZOLE AND INDOLONE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | PFIZER LIMTED (GB) | 2005-12-08 | — | — | WO | disclosed |