Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 13/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | THPO | P40225 | 1/20 | 1.00 |
| ▸ | MTOR | P42345 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 0.98 |
| ▸ | LMNA | P02545 | 1/20 | 0.98 |
| ▸ | MAPT | P10636 | 1/20 | 0.98 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.98 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.98 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aptiganel SCHEMBL30481113 | 1.00 | SIGMAR1 (1.00) | SIGMAR1TP53CYP2D6TSHRTHPO | |
| Aptiganel SCHEMBL21775476 | 1.00 | SIGMAR1 (1.00) | SIGMAR1TP53CYP2D6TSHRTHPO | |
| Aptiganel SCHEMBL151145 | 1.00 | SIGMAR1 (1.00) | SIGMAR1TP53CYP2D6TSHRTHPO | |
| Aptiganel SCHEMBL7414862 | 0.99 | SIGMAR1 (1.00) | SIGMAR1TP53CYP2D6TSHRTHPO | |
| SCHEMBL6719553 | 0.86 | SIGMAR1 (1.00) | SIGMAR1TP53CYP2D6TSHRTHPO | |
| SCHEMBL6727461 | 0.84 | SIGMAR1 (0.73) | SIGMAR1TP53CYP2D6TSHRTHPO | |
| SCHEMBL6719522 | 0.84 | SIGMAR1 (1.00) | SIGMAR1TP53CYP2D6TSHRTHPO | |
| SCHEMBL16887967 | 0.83 | SIGMAR1 (0.71) | SIGMAR1TP53CYP2D6TSHRTHPO | |
| Hydrochloric Acid SCHEMBL7412867 | 0.82 | SIGMAR1 (0.97) | SIGMAR1TP53CYP2D6TSHRTHPO | |
| SCHEMBL6728156 | 0.81 | SIGMAR1 (1.00) | SIGMAR1TP53CYP2D6TSHRTHPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110831584-B | Targeted drug rescue with novel compositions, combinations and methods thereof | 埃克塞瓦有限责任公司 | 2023-03-10 | — | — | CN | claimed |
| CN-110831584-B | Targeted drug rescue with novel compositions, combinations and methods thereof | 埃克塞瓦有限责任公司 | 2023-03-10 | — | — | CN | disclosed |