SCHEMBL30417587

SCHEMBL30417587

CCNC(=NS(=O)(=O)c1ccc(N)c(Cl)c1)N1CC2(C=N1)CCNCC2

nearest known ligand 0.61

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
HTR6 P50406 20/20 0.61
CHRM2 P08172 1/20 0.53
CHRM4 P08173 1/20 0.53
HTR1A P08908 1/20 0.53
CHRM5 P08912 1/20 0.53
CHRM1 P11229 1/20 0.53
CHRM3 P20309 1/20 0.53
HTR1D P28221 1/20 0.53
HTR3A P46098 1/20 0.53
KCNH2 Q12809 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8000310 1.00 HTR6 (0.61) HTR6CHRM2CHRM4HTR1ACHRM5
SCHEMBL30418506 0.92 HTR6 (0.71) HTR6CHRM2CHRM4HTR1ACHRM5
SCHEMBL7988031 0.92 HTR6 (0.71) HTR6CHRM2CHRM4HTR1ACHRM5
SCHEMBL7998250 0.90 HTR6 (0.60) HTR6CHRM2CHRM4HTR1ACHRM5
SCHEMBL1179300 0.87 HTR6 (0.67) HTR6CHRM2CHRM4HTR1ACHRM5
SCHEMBL1179301 0.87 HTR6 (0.67) HTR6CHRM2CHRM4HTR1ACHRM5
SCHEMBL7997566 0.86 HTR6 (0.55) HTR6CHRM2CHRM4HTR1ACHRM5
SCHEMBL1178934 0.86 HTR6 (0.55) HTR6CHRM2CHRM4HTR1ACHRM5
SCHEMBL1178930 0.86 HTR6 (0.55) HTR6CHRM2CHRM4HTR1ACHRM5
SCHEMBL13303316 0.86 HTR6 (0.72) HTR6CHRM2CHRM4HTR1ACHRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023213801-A1 PRE-TARGETING PRECIRIX N.V. (BE) 2023-11-09 WO disclosed
WO-2023203135-A1 IMPROVED RADIOLABELLED ANTIBODY PRECIRIX N.V. (BE) 2023-10-26 WO disclosed
EP-4178982-A1 ANTIBODY FRAGMENT AGAINST FOLR1 Precirix N.V. (BE) 2023-05-17 EP disclosed