Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 12/20 | 0.42 |
| ▸ | JAK3 | P52333 | 11/20 | 0.42 |
| ▸ | JAK2 | O60674 | 5/20 | 0.42 |
| ▸ | TYK2 | P29597 | 3/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
| ▸ | PDE9A | O76083 | 1/20 | 0.39 |
| ▸ | PDE1A | P54750 | 2/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.39 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22684184 | 0.87 | TRPV4 (0.46) | TRPV4LRRK2PDE9APDE1APDE1B | |
| SCHEMBL1717322 | 0.84 | JAK1 (0.41) | JAK1JAK3JAK2TYK2PDE4B | |
| SCHEMBL26927830 | 0.82 | PLAT (0.44) | JAK1JAK3TYK2 | |
| SCHEMBL2999570 | 0.77 | PDE9A (0.38) | TRPV4JAK1JAK3JAK2TYK2 | |
| SCHEMBL5021081 | 0.76 | LRRK2 (0.43) | LRRK2PDE9APDE1APDE1BPDE1C | |
| SCHEMBL17102310 | 0.76 | LRRK2 (0.43) | TRPV4LRRK2PDE9APDE1APDE1B | |
| SCHEMBL22363264 | 0.76 | LRRK2 (0.44) | LRRK2PDE9APDE1APDE1BPDE1C | |
| SCHEMBL19434450 | 0.76 | PDE4B (0.39) | JAK1JAK3JAK2TYK2PDE4B | |
| SCHEMBL19434460 | 0.76 | PDE4B (0.41) | JAK1JAK3JAK2TYK2PDE4B | |
| SCHEMBL7883835 | 0.75 | TYK2 (0.41) | JAK1JAK3JAK2TYK2PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116209664-A | Small molecule modulators of IL-17 | 利奥制药有限公司 | 2023-06-02 | — | — | CN | disclosed |