Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 11/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.62 |
| ▸ | FYN | P06241 | 6/20 | 0.57 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.55 |
| ▸ | IKBKB | O14920 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3042139 | 1.00 | PIM1 (0.62) | PIM1KCNH2FYNMKNK1IKBKB | |
| SCHEMBL1053282 | 0.88 | FYN (0.73) | PIM1KCNH2FYNMKNK1 | |
| SCHEMBL3033353 | 0.87 | FYN (0.67) | PIM1KCNH2FYNMKNK1IKBKB | |
| SCHEMBL2949428 | 0.87 | FYN (0.67) | PIM1KCNH2FYNMKNK1IKBKB | |
| SCHEMBL2947994 | 0.87 | FYN (0.65) | PIM1KCNH2FYNMKNK1IKBKB | |
| SCHEMBL3033272 | 0.87 | FYN (0.65) | PIM1KCNH2FYNMKNK1IKBKB | |
| SCHEMBL3041628 | 0.86 | PIM1 (0.66) | PIM1KCNH2FYNMKNK1 | |
| SCHEMBL3041625 | 0.86 | PIM1 (0.66) | PIM1KCNH2FYNMKNK1 | |
| SCHEMBL4696853 | 0.84 | PIM1 (0.52) | PIM1KCNH2FYNMKNK1IKBKB | |
| SCHEMBL3042041 | 0.84 | FYN (0.80) | PIM1KCNH2FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100216798-A1 | FUSED HETEROCYCLES AS LCK INHIBITORS | ASTELLAS PHARMA INC (JP) | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216798-A1 | FUSED HETEROCYCLES AS LCK INHIBITORS | LCK, ZAP70, FYN | PIM1 138/4885KCNH2 235/4885FYN 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.