Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 10/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.52 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.52 |
| ▸ | FYN | P06241 | 6/20 | 0.48 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3042136 | 0.84 | PIM1 (0.62) | PIM1KCNH2MKNK1FYNIKBKB | |
| SCHEMBL3042139 | 0.84 | PIM1 (0.62) | PIM1KCNH2MKNK1FYNIKBKB | |
| SCHEMBL16009796 | 0.78 | FYN (0.53) | PIM1KCNH2MKNK1FYNIKBKB | |
| SCHEMBL17849259 | 0.78 | FYN (0.53) | PIM1KCNH2MKNK1FYNIKBKB | |
| SCHEMBL16009798 | 0.78 | FYN (0.53) | PIM1KCNH2MKNK1FYNIKBKB | |
| SCHEMBL2947994 | 0.78 | FYN (0.65) | PIM1KCNH2MKNK1FYNIKBKB | |
| SCHEMBL3033272 | 0.78 | FYN (0.65) | PIM1KCNH2MKNK1FYNIKBKB | |
| SCHEMBL3041628 | 0.77 | PIM1 (0.66) | PIM1KCNH2MKNK1FYN | |
| SCHEMBL3041625 | 0.77 | PIM1 (0.66) | PIM1KCNH2MKNK1FYN | |
| SCHEMBL2943219 | 0.77 | MKNK1 (0.64) | PIM1KCNH2MKNK1FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1900739-A1 | Diazolodiazine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | claimed |
| WO-2008025822-A1 | DIAZOLODIAZINE DERIVATIVES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | claimed |
| EP-1900739-A1 | Diazolodiazine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2008025822-A1 | DIAZOLODIAZINE DERIVATIVES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | disclosed |