Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 5/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | SCD | O00767 | 1/20 | 0.35 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31148362 | 1.00 | PTPN11 (0.49) | PTPN11GPR119TP53THRBHSD11B1 | |
| SCHEMBL25214352 | 0.94 | PTPN11 (0.51) | PTPN11GPR119TP53THRBMEN1 | |
| SCHEMBL30422842 | 0.92 | PTPN11 (0.50) | PTPN11GPR119TP53THRBMEN1 | |
| SCHEMBL30421627 | 0.91 | PTPN11 (0.49) | PTPN11GPR119TP53THRBMEN1 | |
| SCHEMBL31485467 | 0.86 | HSD11B1 (0.40) | PTPN11HSD11B1MAPT | |
| SCHEMBL25438924 | 0.84 | PTPN11 (0.50) | PTPN11GPR119TP53MEN1MAPT | |
| SCHEMBL30423069 | 0.84 | PTPN11 (0.50) | PTPN11GPR119TP53MEN1MAPT | |
| SCHEMBL25210578 | 0.84 | PTPN11 (0.45) | PTPN11MAPT | |
| SCHEMBL25211423 | 0.83 | PTPN11 (0.39) | PTPN11TP53MAPT | |
| SCHEMBL30422643 | 0.83 | PTPN11 (0.39) | PTPN11TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4441042-A1 | 5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND METHODS OF USING THE SAME | Rgenta Therapeutics, Inc. (US) | 2024-10-09 | — | — | EP | disclosed |
| WO-2023102231-A1 | 5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND METHODS OF USING THE SAME | RGENTA THERAPEUTICS, INC. (US) | 2023-06-08 | — | — | WO | disclosed |