Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.41 |
| ▸ | EP300 | Q09472 | 1/20 | 0.32 |
| ▸ | RAF1 | P04049 | 4/20 | 0.31 |
| ▸ | BRAF | P15056 | 4/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.31 |
| ▸ | AKT1 | P31749 | 2/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.31 |
| ▸ | WEE1 | P30291 | 1/20 | 0.30 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24253653 | 1.00 | PDE10A (0.41) | PDE10AEP300RAF1BRAFPIK3CD | |
| SCHEMBL24253869 | 0.95 | PDE10A (0.36) | PDE10AEP300WEE1 | |
| SCHEMBL24253840 | 0.90 | PDE10A (0.31) | PDE10A | |
| SCHEMBL24253951 | 0.88 | PDE10A (0.37) | PDE10AEP300RAF1BRAFAKT1 | |
| SCHEMBL30423914 | 0.88 | PDE10A (0.37) | PDE10AEP300RAF1BRAFAKT1 | |
| SCHEMBL24253867 | 0.87 | — | — | |
| SCHEMBL30494592 | 0.86 | EP300 (0.35) | PDE10AEP300RAF1BRAFPIK3CD | |
| SCHEMBL24253647 | 0.86 | EP300 (0.35) | PDE10AEP300RAF1BRAFPIK3CD | |
| SCHEMBL24253950 | 0.85 | GPR119 (0.36) | PDE10AEP300 | |
| SCHEMBL24253733 | 0.84 | PDE10A (0.33) | PDE10AEP300AKT1PIK3CAWEE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4196478-A1 | HETEROARYL SUBSTITUTED SPIROPIPERIDINYL DERIVATIVES AND PHARMACEUTICAL USES THEREOF | Novartis AG (CH) | 2023-06-21 | — | — | EP | claimed |
| CN-116157404-A | Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof | 诺华股份有限公司 | 2023-05-23 | — | — | CN | claimed |
| EP-4196478-A1 | HETEROARYL SUBSTITUTED SPIROPIPERIDINYL DERIVATIVES AND PHARMACEUTICAL USES THEREOF | Novartis AG (CH) | 2023-06-21 | — | — | EP | disclosed |
| CN-116157404-A | Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof | 诺华股份有限公司 | 2023-05-23 | — | — | CN | disclosed |