Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1S1 | Q96B36 | 5/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 5/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 2/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24253830 | 1.00 | AKT1S1 (0.36) | AKT1S1CYP11B2RAD51TP53MAPT | |
| SCHEMBL24253532 | 0.89 | CYP11B2 (0.32) | AKT1S1CYP11B2PDE4BAKT1 | |
| SCHEMBL30423549 | 0.89 | CYP11B2 (0.32) | AKT1S1CYP11B2PDE4BAKT1 | |
| SCHEMBL30423561 | 0.88 | DPP4 (0.36) | AKT1S1CYP11B2RAD51CNR1ALDH1A1 | |
| SCHEMBL24253726 | 0.88 | DPP4 (0.36) | AKT1S1CYP11B2RAD51CNR1ALDH1A1 | |
| SCHEMBL24253921 | 0.83 | RAD51 (0.31) | RAD51 | |
| SCHEMBL30424173 | 0.83 | RAD51 (0.31) | RAD51 | |
| SCHEMBL24253536 | 0.82 | DPP4 (0.36) | CYP11B2RAD51AKT1HCRTR1HCRTR2 | |
| SCHEMBL30494533 | 0.82 | DPP4 (0.36) | CYP11B2RAD51AKT1HCRTR1HCRTR2 | |
| SCHEMBL24253919 | 0.81 | RAD51 (0.31) | RAD51 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4196478-A1 | HETEROARYL SUBSTITUTED SPIROPIPERIDINYL DERIVATIVES AND PHARMACEUTICAL USES THEREOF | Novartis AG (CH) | 2023-06-21 | — | — | EP | claimed |
| CN-116157404-A | Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof | 诺华股份有限公司 | 2023-05-23 | — | — | CN | claimed |
| EP-4196478-A1 | HETEROARYL SUBSTITUTED SPIROPIPERIDINYL DERIVATIVES AND PHARMACEUTICAL USES THEREOF | Novartis AG (CH) | 2023-06-21 | — | — | EP | disclosed |
| CN-116157404-A | Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof | 诺华股份有限公司 | 2023-05-23 | — | — | CN | disclosed |