Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.33 |
| ▸ | EIF2AK4 | Q9P2K8 | 2/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.31 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.31 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | CDK4 | P11802 | 1/20 | 0.30 |
| ▸ | CCND1 | P24385 | 1/20 | 0.30 |
| ▸ | CCND3 | P30281 | 1/20 | 0.30 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24253828 | 1.00 | HCRTR1 (0.33) | HCRTR1HCRTR2KCNH2LTC4SEIF2AK4 | |
| SCHEMBL24253827 | 0.96 | AOC3 (0.33) | HCRTR1HCRTR2KCNH2LTC4SEIF2AK4 | |
| SCHEMBL30424094 | 0.96 | AOC3 (0.33) | HCRTR1HCRTR2KCNH2LTC4SEIF2AK4 | |
| SCHEMBL30423990 | 0.92 | CYP11B2 (0.35) | HCRTR1HCRTR2KCNH2LTC4SEIF2AK4 | |
| SCHEMBL30423539 | 0.82 | KMT2A (0.41) | HCRTR1HCRTR2AOC3ALDH1A1 | |
| SCHEMBL24253712 | 0.82 | KMT2A (0.41) | HCRTR1HCRTR2AOC3ALDH1A1 | |
| SCHEMBL24253933 | 0.81 | HCRTR1 (0.32) | HCRTR1HCRTR2KCNH2LTC4S | |
| SCHEMBL30423566 | 0.81 | HCRTR1 (0.32) | HCRTR1HCRTR2KCNH2LTC4S | |
| SCHEMBL24253726 | 0.81 | DPP4 (0.36) | HCRTR1HCRTR2KCNH2LTC4SAOC3 | |
| SCHEMBL30423561 | 0.81 | DPP4 (0.36) | HCRTR1HCRTR2KCNH2LTC4SAOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4196478-A1 | HETEROARYL SUBSTITUTED SPIROPIPERIDINYL DERIVATIVES AND PHARMACEUTICAL USES THEREOF | Novartis AG (CH) | 2023-06-21 | — | — | EP | claimed |
| CN-116157404-A | Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof | 诺华股份有限公司 | 2023-05-23 | — | — | CN | claimed |
| EP-4196478-A1 | HETEROARYL SUBSTITUTED SPIROPIPERIDINYL DERIVATIVES AND PHARMACEUTICAL USES THEREOF | Novartis AG (CH) | 2023-06-21 | — | — | EP | disclosed |
| CN-116157404-A | Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof | 诺华股份有限公司 | 2023-05-23 | — | — | CN | disclosed |