Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.57 |
| ▸ | CCR1 | P32246 | 3/20 | 0.57 |
| ▸ | CCR5 | P51681 | 3/20 | 0.57 |
| ▸ | CCR8 | P51685 | 3/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.57 |
| ▸ | METAP1 | P53582 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.52 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.52 |
| ▸ | GRM5 | P41594 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | ALPL | P05186 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1442585 | 1.00 | TDP1 (0.68) | TDP1KDM4EL3MBTL1CCR1CCR5 | |
| SCHEMBL29545764 | 0.92 | CCR1 (0.63) | TDP1KDM4EL3MBTL1CCR1CCR5 | |
| SCHEMBL4490247 | 0.92 | CCR1 (0.63) | TDP1KDM4EL3MBTL1CCR1CCR5 | |
| SCHEMBL10157013 | 0.87 | KDM4E (0.57) | TDP1KDM4EL3MBTL1CCR1CCR5 | |
| SCHEMBL5480168 | 0.87 | GRM5 (0.61) | TDP1KDM4EMETAP1LMNAGRM5 | |
| SCHEMBL30424441 | 0.87 | L3MBTL1 (0.58) | TDP1KDM4EL3MBTL1CCR1CCR5 | |
| SCHEMBL1444155 | 0.87 | L3MBTL1 (0.58) | TDP1KDM4EL3MBTL1CCR1CCR5 | |
| SCHEMBL9487125 | 0.87 | KDM4E (0.57) | TDP1KDM4EL3MBTL1CCR1CCR5 | |
| SCHEMBL1271821 | 0.86 | KDM4E (0.55) | TDP1KDM4EL3MBTL1CCR1CCR5 | |
| SCHEMBL2721755 | 0.83 | KDM4E (0.52) | TDP1KDM4EL3MBTL1CCR1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116157404-A | Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof | 诺华股份有限公司 | 2023-05-23 | — | — | CN | disclosed |