Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.33 |
| ▸ | METTL3 | Q86U44 | 2/20 | 0.33 |
| ▸ | DPP4 | P27487 | 6/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24253866 | 1.00 | HCRTR1 (0.35) | HCRTR1HCRTR2KCNH2LTC4SHTR1A | |
| SCHEMBL24253540 | 0.86 | HCRTR1 (0.34) | HCRTR1HCRTR2KCNH2LTC4SHTR1A | |
| SCHEMBL30424148 | 0.84 | ELOVL1 (0.41) | HTR1ADRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL24253644 | 0.84 | ELOVL1 (0.41) | HTR1ADRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL24253552 | 0.84 | MAPT (0.40) | HCRTR1HCRTR2KCNH2LTC4SHTR1A | |
| SCHEMBL30423245 | 0.84 | MAPT (0.40) | HCRTR1HCRTR2KCNH2LTC4SHTR1A | |
| SCHEMBL24253832 | 0.84 | HCRTR2 (0.33) | HCRTR1HCRTR2KCNH2LTC4SHTR1A | |
| SCHEMBL24253834 | 0.83 | HCRTR1 (0.33) | HCRTR1HCRTR2KCNH2LTC4SHTR1A | |
| SCHEMBL24253536 | 0.82 | DPP4 (0.36) | HCRTR1HCRTR2KCNH2LTC4SMETTL3 | |
| SCHEMBL30494533 | 0.82 | DPP4 (0.36) | HCRTR1HCRTR2KCNH2LTC4SMETTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4196478-A1 | HETEROARYL SUBSTITUTED SPIROPIPERIDINYL DERIVATIVES AND PHARMACEUTICAL USES THEREOF | Novartis AG (CH) | 2023-06-21 | — | — | EP | disclosed |
| CN-116157404-A | Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof | 诺华股份有限公司 | 2023-05-23 | — | — | CN | disclosed |