Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 6/20 | 0.56 |
| ▸ | TEAD4 | Q15561 | 6/20 | 0.56 |
| ▸ | TEAD2 | Q15562 | 6/20 | 0.56 |
| ▸ | TEAD3 | Q99594 | 6/20 | 0.56 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.35 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25205816 | 1.00 | TEAD1 (0.56) | TEAD1TEAD4TEAD2TEAD3NR3C1 | |
| SCHEMBL25751652 | 0.93 | TEAD1 (0.56) | TEAD1TEAD4TEAD2TEAD3NR3C1 | |
| SCHEMBL30424153 | 0.93 | TEAD1 (0.56) | TEAD1TEAD4TEAD2TEAD3NR3C1 | |
| SCHEMBL25751589 | 0.91 | TEAD1 (0.55) | TEAD1TEAD4TEAD2TEAD3NR3C1 | |
| SCHEMBL30424418 | 0.91 | TEAD1 (0.55) | TEAD1TEAD4TEAD2TEAD3NR3C1 | |
| SCHEMBL25751575 | 0.89 | TEAD1 (0.55) | TEAD1TEAD4TEAD2TEAD3NR3C1 | |
| SCHEMBL30423410 | 0.89 | TEAD1 (0.55) | TEAD1TEAD4TEAD2TEAD3NR3C1 | |
| SCHEMBL25245319 | 0.88 | TEAD1 (0.59) | TEAD1TEAD4TEAD2TEAD3NR3C1 | |
| SCHEMBL29266839 | 0.88 | TEAD1 (0.52) | TEAD1TEAD4TEAD2TEAD3NR3C1 | |
| SCHEMBL30424431 | 0.87 | TEAD1 (0.56) | TEAD1TEAD4TEAD2TEAD3NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4436957-A1 | THERAPEUTIC INDAZOLE COMPOUNDS AND METHODS OF USE IN THE TREATMENT OF CANCER | Genentech, Inc. (US) | 2024-10-02 | — | — | EP | disclosed |
| CN-118302411-A | Therapeutic indazole compounds and methods of use thereof for the treatment of cancer | 基因泰克公司 | 2024-07-05 | — | — | CN | disclosed |
| WO-2023097195-A1 | THERAPEUTIC INDAZOLE COMPOUNDS AND METHODS OF USE IN THE TREATMENT OF CANCER | GENENTECH, INC. (US) | 2023-06-01 | — | — | WO | disclosed |