Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 6/20 | 0.56 |
| ▸ | TEAD4 | Q15561 | 6/20 | 0.56 |
| ▸ | TEAD2 | Q15562 | 6/20 | 0.56 |
| ▸ | TEAD3 | Q99594 | 6/20 | 0.56 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.35 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.34 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.33 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25750800 | 1.00 | TEAD1 (0.56) | TEAD1TEAD4TEAD2TEAD3NR3C1 | |
| SCHEMBL30989248 | 0.92 | TEAD1 (0.56) | TEAD1TEAD4TEAD2TEAD3NR3C1 | |
| SCHEMBL25750672 | 0.92 | TEAD1 (0.56) | TEAD1TEAD4TEAD2TEAD3NR3C1 | |
| SCHEMBL25209770 | 0.88 | TEAD1 (0.60) | TEAD1TEAD4TEAD2TEAD3NR3C1 | |
| SCHEMBL25245319 | 0.88 | TEAD1 (0.59) | TEAD1TEAD4TEAD2TEAD3NR3C1 | |
| SCHEMBL30424287 | 0.87 | TEAD1 (0.56) | TEAD1TEAD4TEAD2TEAD3NR3C1 | |
| SCHEMBL30424153 | 0.87 | TEAD1 (0.56) | TEAD1TEAD4TEAD2TEAD3NR3C1 | |
| SCHEMBL25205816 | 0.87 | TEAD1 (0.56) | TEAD1TEAD4TEAD2TEAD3NR3C1 | |
| SCHEMBL25751652 | 0.87 | TEAD1 (0.56) | TEAD1TEAD4TEAD2TEAD3NR3C1 | |
| SCHEMBL25751808 | 0.87 | TEAD1 (0.41) | TEAD1TEAD4TEAD2TEAD3L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250074881-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2025-03-06 | — | — | US | disclosed |
| US-12110276-B2 | Pyrazolo compounds and methods of use thereof | GENENTECH, INC. (US) | 2024-10-08 | — | — | US | disclosed |
| EP-4436957-A1 | THERAPEUTIC INDAZOLE COMPOUNDS AND METHODS OF USE IN THE TREATMENT OF CANCER | Genentech, Inc. (US) | 2024-10-02 | — | — | EP | disclosed |
| CN-118302411-A | Therapeutic indazole compounds and methods of use thereof for the treatment of cancer | 基因泰克公司 | 2024-07-05 | — | — | CN | disclosed |
| US-20230202984-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2023-06-29 | — | — | US | disclosed |
| WO-2023097195-A1 | THERAPEUTIC INDAZOLE COMPOUNDS AND METHODS OF USE IN THE TREATMENT OF CANCER | GENENTECH, INC. (US) | 2023-06-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250074881-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE | VHL, TP53, MCL1 | TEAD1 282/4885TEAD4 162/4885TEAD2 129/4885 |
| US-20230202984-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE | VHL, TP53, MCL1 | TEAD1 282/4885TEAD4 162/4885TEAD2 129/4885 |
| US-12110276-B2 | Pyrazolo compounds and methods of use thereof | THPO, KLK3, TP53 | TEAD1 390/4885TEAD4 240/4885TEAD2 200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.