Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.31 |
| ▸ | MTOR | P42345 | 2/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24253936 | 1.00 | PIK3CA (0.31) | PIK3CAMTORPDK2HTR1ADRD2 | |
| SCHEMBL24253808 | 0.84 | DPP4 (0.32) | PIK3CAMTORPDK2HTR1ADRD2 | |
| SCHEMBL30424172 | 0.82 | F10 (0.32) | — | |
| SCHEMBL24253541 | 0.82 | F10 (0.32) | — | |
| SCHEMBL24253620 | 0.80 | MLYCD (0.32) | HTR1ADRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL30006991 | 0.79 | KDM4E (0.32) | HTR1ADRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL24253946 | 0.79 | KDM4E (0.32) | HTR1ADRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL24253737 | 0.78 | HCRTR1 (0.33) | HTR1ADRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL24253889 | 0.78 | HRH4 (0.32) | HTR1ADRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL30006004 | 0.78 | HRH4 (0.32) | HTR1ADRD2ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4196478-A1 | HETEROARYL SUBSTITUTED SPIROPIPERIDINYL DERIVATIVES AND PHARMACEUTICAL USES THEREOF | Novartis AG (CH) | 2023-06-21 | — | — | EP | claimed |
| CN-116157404-A | Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof | 诺华股份有限公司 | 2023-05-23 | — | — | CN | claimed |
| EP-4196478-A1 | HETEROARYL SUBSTITUTED SPIROPIPERIDINYL DERIVATIVES AND PHARMACEUTICAL USES THEREOF | Novartis AG (CH) | 2023-06-21 | — | — | EP | disclosed |
| CN-116157404-A | Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof | 诺华股份有限公司 | 2023-05-23 | — | — | CN | disclosed |