Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 14/20 | 0.64 |
| ▸ | PI4KA | P42356 | 14/20 | 0.64 |
| ▸ | PI4KB | Q9UBF8 | 14/20 | 0.64 |
| ▸ | PIK3CD | O00329 | 12/20 | 0.64 |
| ▸ | PIK3CG | P48736 | 11/20 | 0.64 |
| ▸ | PIK3CB | P42338 | 10/20 | 0.64 |
| ▸ | PIP5K1C | O60331 | 4/20 | 0.53 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | STAT1 | P42224 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25240955 | 1.00 | PIK3CA (0.64) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL25267881 | 0.89 | PIK3CA (0.54) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL30425066 | 0.86 | HDAC6 (0.50) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL25216541 | 0.86 | HDAC6 (0.50) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL30424712 | 0.82 | HDAC6 (0.42) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL25387357 | 0.82 | HDAC6 (0.42) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL30424948 | 0.81 | KCNH2 (0.41) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL25236686 | 0.81 | KCNH2 (0.41) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL25386557 | 0.80 | HDAC6 (0.40) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL30424439 | 0.80 | HDAC6 (0.40) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116157398-B | Oxadiazole-based selective histone deacetylase 6 inhibitors | 意大发马克股份公司 | 2025-03-11 | — | — | CN | claimed |
| CN-116157398-A | 2- (4- ((5- (benzo [ b ] thiophen-3-yl) -1H-tetrazol-1-yl) methyl) phenyl) -5- (difluoromethyl) -1,3, 4-oxadiazole derivatives and similar compounds as selective inhibitors of histone deacetylase 6 (HDAC 6) for the treatment of, for example, peripheral neuropathy | 意大发马克股份公司 | 2023-05-23 | — | — | CN | claimed |
| CN-116157398-B | Oxadiazole-based selective histone deacetylase 6 inhibitors | 意大发马克股份公司 | 2025-03-11 | — | — | CN | disclosed |
| CN-116157398-A | 2- (4- ((5- (benzo [ b ] thiophen-3-yl) -1H-tetrazol-1-yl) methyl) phenyl) -5- (difluoromethyl) -1,3, 4-oxadiazole derivatives and similar compounds as selective inhibitors of histone deacetylase 6 (HDAC 6) for the treatment of, for example, peripheral neuropathy | 意大发马克股份公司 | 2023-05-23 | — | — | CN | disclosed |