Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 11/20 | 0.79 |
| ▸ | GAA | P10253 | 11/20 | 0.79 |
| ▸ | SI | P14410 | 11/20 | 0.79 |
| ▸ | MGAM2 | Q2M2H8 | 11/20 | 0.79 |
| ▸ | PARP1 | P09874 | 5/20 | 0.67 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.52 |
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30425376 | 0.85 | PARP1 (0.66) | MGAMGAASIMGAM2PARP1 | |
| SCHEMBL8814874 | 0.83 | PARP1 (0.63) | MGAMGAASIMGAM2PARP1 | |
| SCHEMBL24141172 | 0.83 | MGAM (0.77) | MGAMGAASIMGAM2PARP1 | |
| SCHEMBL6056819 | 0.81 | MGAM (0.68) | MGAMGAASIMGAM2PARP1 | |
| SCHEMBL29400277 | 0.81 | ALOX5 (0.55) | MGAMGAASIMGAM2PARP1 | |
| SCHEMBL24266636 | 0.81 | ALOX5 (0.55) | MGAMGAASIMGAM2PARP1 | |
| SCHEMBL12470605 | 0.78 | ALOX5 (0.70) | GAAPARP1ALOX5EPHX2KDM4E | |
| SCHEMBL5201575 | 0.78 | MGAM (0.68) | MGAMGAASIMGAM2KDM4E | |
| SCHEMBL6056826 | 0.77 | MGAM (0.77) | MGAMGAASIMGAM2PARP1 | |
| SCHEMBL14012670 | 0.77 | MGAM (0.65) | MGAMGAASIMGAM2PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116075510-A | 1H-benzo [ d ] imidazole derivatives as TLR9 inhibitors for the treatment of fibrosis | 百时美施贵宝公司 | 2023-05-05 | — | — | CN | claimed |
| CN-116075510-A | 1H-benzo [ d ] imidazole derivatives as TLR9 inhibitors for the treatment of fibrosis | 百时美施贵宝公司 | 2023-05-05 | — | — | CN | disclosed |